This research is based on the assumption that social media sites – such as Facebook, Twitter and YouTube – have changed the way in which memes (culturally transmitted ideas) are transmitted or spread. Qualitative research is used in this study, particularly a literature study that applies and weighs the theories against a purposive sample of selected film examples between 2009 and 2010, to answer the question: what is the relationship between social media sites and the spread of memes? To answer this question, the way in which social media aids the spread of memes is analysed. It is argued that social media has provided the most fertile environment for the replication of memes to date. Also analysed is the way in which social media sites are represented in films, as well as the ways in which the offline lives of the characters are affected by their social media profiles, specifically as depicted in films Julie & Julia (Ephron 2009), Trust (Schwimmer 2010), and Catfish (Joost & Schulman 2010). Lastly, it is argued that one can construct an entirely new persona, or merely experiment with different aspects of who you are, on social media sites. This online persona can be influenced by the memes one chooses to spread online. Naturally, all memes carry connotations, values and judgements. These memes collaborate with one’s profile and, thus, the connotations attached to the memes one shares are then associated with one’s online persona (profile). This research is deemed relevant, also in a South African context, because the spread of memes does not respect national or international boundaries.