Identification of drugs effective against Cowdria ruminantium using a mouse screening system

Heartwater : Past, Present and Future. Workshop (1986 : Kruger National Park, South Africa); McHardy, N.; MacKenzie, P.K.I.

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dc.contributor.author	Heartwater : Past, Present and Future. Workshop (1986 : Kruger National Park, South Africa)
dc.contributor.author	McHardy, N.
dc.contributor.author	MacKenzie, P.K.I.
dc.contributor.editor	Bigalke, R.D.
dc.date.accessioned	2014-12-05T08:30:29Z
dc.date.available	2014-12-05T08:30:29Z
dc.date.created	2014
dc.date.issued	1987
dc.description	The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.	en_US
dc.description.abstract	Heartwater is a tick-transmitted rickettsial infection of ruminants, caused by Cowdria ruminantium. The tetracyclines are the only compounds available for therapy of the disease. A screen, using mice infected with C. ruminantium, was developed and used to identify new compounds with potential for the control of heartwater. A series of di-4-methyl-thiosemicarbazones was shown to be highly active in the mouse model and their efficacy was confirmed in further trials in sheep infected with C. ruminantium. The mouse screen was shown to be simple to operate and reliably predictive of activity against heartwater. Ways in which the screen may be improved are suggested.	en_US
dc.description.librarian	lmchunu2014	en_US
dc.description.librarian	mn2014
dc.identifier.citation	McHardy, N & MacKenzie, PKI 1987, 'Identification of drugs effective against Cowdria ruminantium using a mouse screening system’, Onderstepoort Journal of Veterinary Research, vol. 54, no. 3, pp. 481-484.	en_US
dc.identifier.issn	0330-2465
dc.identifier.uri	http://hdl.handle.net/2263/42810
dc.language.iso	en	en_US
dc.publisher	Published by the Government Printer, Pretoria.	en_US
dc.rights	©ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©University of Pretoria. Dept. of Library Services (digital).	en_US
dc.subject	Veterinary medicine	en_US
dc.subject.lcsh	Veterinary medicine -- South Africa
dc.subject.lcsh	Heartwater -- South Africa	en
dc.title	Identification of drugs effective against Cowdria ruminantium using a mouse screening system	en_US
dc.title.alternative	Heartwater : past, present and future : proceedings of a workshop held at Berg en Dal, Kruger National Park, on 8-16 September 1986
dc.type	Article	en_US