The pathogenesis of heartwater
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Date
Authors
Heartwater : Past, Present and Future. Workshop (1986 : Kruger National Park, South Africa)
Du Plessis, J.L.
Malan, Letitia
Kowalski, Z.E.
Journal Title
Journal ISSN
Volume Title
Publisher
Published by the Government Printer, Pretoria.
Abstract
Hypotheses on the pathogenesis of heartwater, which have been published so far, are briefly reviewed. Attempts were made at counteracting the effects of vaso-active substances released by mast cells by treating mice infected with Cowdria ruminantium with antagonists to histamin and serotonin on one hand, and with mast cell stabilizers on the other, but were not successful. Preliminary findings suggest that a hypersensitive type of reaction, triggered by the release of pharmacologically active substances, may possibly be basic to the pathogenesis of heartwater. Complement, and the products of arachidonic acid metabolism, possibly play a role in the release of the vaso-active substances.
Description
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Keywords
Veterinary medicine
Sustainable Development Goals
Citation
Du Plessis, JL, Malan, L & Kowalski, ZE 1987, 'The pathogenesis of heartwater’, Onderstepoort Journal of Veterinary Research, vol. 54, no. 3, pp. 313-318.