Anesthetic technique (sufentanil versus ketamine plus midazolam) and quantitative electroencephalographic changes after cardiac surgery

Show simple item record Smith, Francois Jacobus Bartel, Peter R. Hugo, Johan M. Becker, Piet J. 2008-01-17T11:56:09Z 2008-01-17T11:56:09Z 2006-08
dc.description.abstract OBJECTIVES: Cardiac surgery involving cardiopulmonary bypass is associated with neurologic deterioration. Several interventions, including anesthetic techniques, have been designed to limit ischemic brain damage and have been evaluated in animals. Markers of neurologic injury may facilitate the assessment of these interventions in humans. DESIGN: A blinded randomized prospective study comparing 2 anesthetic techniques (one sufentanil-based, the other ketamine and midazolam–based) in patients undergoing cardiac surgery. Quantitative electroencephalography was used to detect postoperative neurologic injury. SETTING: Major teaching hospital. PARTICIPANTS: Forty-two patients aged 18 to 70 years undergoing cardiac surgery. INTERVENTIONS: Patients were anesthetized with either a sufentanil-based or a ketamine and midazolam–based technique for cardiac surgery with cardiopulmonary bypass. Quantitative electroencephalography was performed preoperatively as well as 5 to 6 days postoperatively. MEASUREMENTS AND MAIN RESULTS: Quantitative electroencephalography outcome did not differ (p > 0.05) between the 2 groups. It showed significant deterioration between preoperative and postoperative assessments with a decrease in faster and an increase in slower frequencies. In addition, the alpha attenuation index decreased. This may reflect a decrease in alertness. Both the intergroup comparisons and the assessment of individual changes failed to reveal significant differences between the anesthetic techniques. The adjuvant use of isoflurane correlated with less deterioration of quantitative electroencephalographic variables. CONCLUSIONS: The use of either sufentanil-based or ketamine and midazolam–based anesthetic techniques for cardiac surgery with cardiopulmonary bypass had no effects on a marker of postoperative neurologic injury (ie, quantitative electroencephalography). en
dc.format.extent 119032 bytes
dc.format.mimetype application/pdf
dc.identifier.citation Smith, FJ, Bartel, PR, Hugo, JM & Becker, PJ 2006 'Anesthetic technique (Sufentanil versus Ketamine plus Midazolam) and quantitative electroencephalographic changes after cardiac surgery', Journal of Cardiothoracic and Vascular Anesthesia, vol. 20, no. 4, pp. 520-525. [] en
dc.identifier.issn 1053-0770
dc.identifier.other 10.1053/j.jvca.2005.11.014
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject Neurologic outcome en
dc.subject Cardiac surgery en
dc.subject Ketamine en
dc.subject Midazolam en
dc.subject Sufentanil en
dc.subject Quantitative electroencephalography en
dc.subject.lcsh Heart -- Surgery
dc.subject.lcsh Neurological emergencies
dc.subject.lcsh Cardiopulmonary bypass
dc.title Anesthetic technique (sufentanil versus ketamine plus midazolam) and quantitative electroencephalographic changes after cardiac surgery en
dc.type Postprint Article en

Files in this item

This item appears in the following Collection(s)

Show simple item record