Evaluation of standard magnetic resonance characteristics used to differentiate neoplastic, inflammatory, and vascular brain lesions in dogs

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dc.contributor.author Young, Benjamin D.
dc.contributor.author Fosgate, Geoffrey T.
dc.contributor.author Holmes, Shannon P.
dc.contributor.author Wolff, Collin A.
dc.contributor.author Chen-Allen, Annie V.
dc.contributor.author Kent, Marc
dc.contributor.author Platt, Simon R.
dc.contributor.author Savage, Mason Y.
dc.contributor.author Schatzberg, Scott J.
dc.contributor.author Levine, Jonathan M.
dc.date.accessioned 2014-10-09T09:27:46Z
dc.date.available 2014-10-09T09:27:46Z
dc.date.issued 2014-07
dc.description.abstract Magnetic resonance (MR) imaging characteristics are commonly used to help predict intracranial disease categories in dogs, however, few large studies have objectively evaluated these characteristics. The purpose of this retrospective study was to evaluate MR characteristics that have been used to differentiate neoplastic, inflammatory, and vascular intracranial diseases in a large, multi-institutional population of dogs. Medical records from three veterinary teaching hospitals were searched over a 6-year period for dogs that had diagnostic quality brain MR scans and histologically confirmed intracranial disease. Three examiners who were unaware of histologic diagnosis independently evaluated 19 MR lesion characteristics totaling 57 possible responses. A total of 75 dogs with histologically confirmed intracranial disease were included in analyses: 51 with neoplasia, 18 with inflammatory disease, and six with cerebrovascular disease. Only strong contrast enhancement was more common in neoplasia than other disease categories. A multivariable statistical model suggested that extra-axial origin, T2-FLAIR mixed intensity, and defined lesion margins were also predictive of neoplasia. Meningeal enhancement, irregular lesion shape, and multifocal location distinguished inflammatory diseases from the other disease categories. No MR characteristics distinguished vascular lesions and these appeared most similar to neoplasia. These results differed from a previous report describing seven MR characteristics that were predictive of neoplasia in dogs and cats. Findings from the current study indicated that the high performance of MR for diagnosing canine intracranial diseases might be due to evaluator recognition of combinations of MR characteristics vs. relying on any one MR characteristic alone. en_US
dc.description.librarian hb2014 en_US
dc.description.uri http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1740-8261 en_US
dc.identifier.citation Young, BD, Fosgate, GT, Holmes, SP, Wolff, CA, Chen-Allen, AV, Kent, M, Platt, SR, Savage, MY, Schatzberg, SJ & Levine, JM 2014, 'Evaluation of standard magnetic resonance characteristics used to differentiate neoplastic, inflammatory, and vascular brain lesions in dogs', Veterinary Radiology and Ultrasound, vol. 55, no. 4, pp. 399-406. en_US
dc.identifier.issn 1058-8183 (print)
dc.identifier.issn 1740-8261 (online)
dc.identifier.other 10.1111/vru.12137
dc.identifier.other 6603440077
dc.identifier.uri http://hdl.handle.net/2263/42316
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2014 American College of Veterinary Radiology. The definite version is available at : http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1740-8261. en_US
dc.subject Brain en_US
dc.subject Dogs en_US
dc.subject Imaging en_US
dc.subject Neoplasia en_US
dc.subject Inflammation en_US
dc.subject MR imaging en_US
dc.subject Magnetic resonance imaging en_US
dc.subject MRI
dc.title Evaluation of standard magnetic resonance characteristics used to differentiate neoplastic, inflammatory, and vascular brain lesions in dogs en_US
dc.type Preprint Article en_US


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