The central role of chloride in the metabolic acid-base changes in canine parvoviral enteritis

Show simple item record Burchell, Richard K. Schoeman, Johan P. Leisewitz, Andrew L. 2014-10-02T11:15:10Z 2014-10-02T11:15:10Z 2014-04
dc.description.abstract The acid–base disturbances in canine parvoviral (CPV) enteritis are not well described. In addition, the mechanisms causing these perturbations have not been fully elucidated. The purpose of the present study was to assess acid–base changes in puppies suffering from CPV enteritis, using a modified strong ion model (SIM). The hypothesis of the study was that severe acid–base disturbances would be present and that the SIM would provide insights into pathological mechanisms, which have not been fully appreciated by the Henderson–Hasselbalch model. The study analysed retrospective data, obtained from 42 puppies with confirmed CPV enteritis and 10 healthy control dogs. The CPV-enteritis group had been allocated a clinical score, to allow classification of the data according to clinical severity. The effects of changes in free water, chloride, L-lactate, albumin and phosphate were calculated, using a modification of the base excess algorithm. When the data were summated for each patient, and correlated to each individual component, the most important contributor to the metabolic acid–base changes, according to the SIM, was chloride (P < 0.001). Severely-affected animals tended to demonstrate hypochloraemic alkalosis, whereas mildly-affected puppies had a hyperchloraemic acidosis (P = 0.007). In conclusion, the acid–base disturbances in CPV enteritis are multifactorial and complex, with the SIM providing information in terms of the origin of these changes. en_US
dc.description.librarian hb2014 en_US
dc.description.uri en_US
dc.identifier.citation Burchell, RK, Schoeman, JP & Leisewitz, AL 2014, 'The central role of chloride in the metabolic acid-base changes in canine parvoviral enteritis', Veterinary Journal, vol. 200, no.1, pp. 152-156. en_US
dc.identifier.issn 1090-0233 (print)
dc.identifier.other 10.1016/j.tvjl.2014.01.017
dc.identifier.other 7005814117
dc.identifier.other C-3865-2012
dc.identifier.other 6701514975
dc.identifier.other J-6765-2013
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2014 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in The Veterinary Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Veterinary Journal, vol. 200, no. 1, pp. 152-156, 2014. doi :10.1016/j.tvjl.2014.01.017. en_US
dc.subject Strong ion model en_US
dc.subject Henderson–Hasselbalch method en_US
dc.subject Canine parvovirus (CPV) en_US
dc.subject.lcsh Dogs -- Diseases en_ZA
dc.title The central role of chloride in the metabolic acid-base changes in canine parvoviral enteritis en_US
dc.type Postprint Article en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record