The impact of co-infections on the haematological profile of East African short-horn Zebu calves

Show simple item record Conradie van Wyk, Ilana Goddard, Amelia Bronsvoort, Barend Mark de Clare Coetzer, Jacobus A.W. Handel, Ian Graham Hanotte, Olivier Jennings, Amy Lesosky, Maia Kiara, Henry Thumbi, Samuel Mwangi Toye, Philip G. Woolhouse, Mark W. Penzhorn, Barend Louis 2014-09-02T08:07:30Z 2014-09-02T08:07:30Z 2014
dc.description The work was done as part of the Infectious Diseases of East African Livestock (IDEAL) project, which is a collaboration between the University of Pretoria, University of Edinburgh, University of Nottingham and the International Livestock Research Institute (ILRI), Nairobi, Kenya. en_US
dc.description.abstract The cumulative effect of co-infections between pathogen pairs on the haematological response of East African Short-horn Zebu calves is described. Using a longitudinal study design a stratified clustered random sample of newborn calves were recruited into the Infectious Diseases of East African Livestock (IDEAL) study and monitored at 5-weekly intervals until 51 weeks of age. At each visit sampleswere collected and analysed to determine the infection status of each calf aswell as their haematological response. The haematological parameters investigated included packed cell volume (PCV), white blood cell count (WBC) and platelet count (Plt). The pathogens of interest included tick-borne protozoa and rickettsias, trypanosomes and intestinal parasites. Generalized additive mixed-effect models were used to model the infectious status of pathogens against each haematological parameter, including significant interactions between pathogens. These models were further used to predict the cumulative effect of co-infecting pathogen pairs on each haematological parameter. The most significant decrease in PCV was found with co-infections of trypanosomes and strongyles. Strongyle infections also resulted in a significant decrease in WBC at a high infectious load. Trypanosomes were the major cause of thrombocytopenia. Platelet counts were also affected by interactions between tick-borne pathogens. Interactions between concomitant pathogens were found to complicate the prognosis and clinical presentation of infected calves and should be taken into consideration in any study that investigates disease under field conditions. en_US
dc.description.librarian am2014 en_US
dc.description.sponsorship The IDEAL project was generously funded by the Wellcome Trust (project no. 079445). The pocH-100iV Diff automated blood analyser was kindly sponsored by Sysmex© Europe GMBH. en_US
dc.description.uri en_US
dc.identifier.citation Van Wyk, IC, Goddard, A., BMDC Bronsvoort, BM, Coetzer, JAW, Handel, IG, Hanotte, O, Jennings, A, Lesosky, M, Kiara, H, Thumbi, SM, Toye, P, Woolhouse, MW & Penzhorn, BL 2014, 'The impact of co-infections on the haematological profile of East African short-horn Zebu calves', Parasitology, vol. 141, no. 3, pp. 374-388. en_US
dc.identifier.issn 0031-1820 (print)
dc.identifier.issn 1469-8161 (online)
dc.identifier.other 10.1017/S0031182013001625
dc.identifier.other 35609781000
dc.identifier.other J-7222-2013
dc.language.iso en en_US
dc.publisher Cambridge University Press en_US
dc.relation.requires Adobe Acrobat Reader en
dc.rights © Cambridge University Press 2013. The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence. en_US
dc.subject Co-infection en_US
dc.subject Platelets en_US
dc.subject Zebus en_US
dc.subject Zebu calves en_US
dc.subject Packed cell volume (PCV) en_US
dc.subject White blood cell count (WBC) en_US
dc.subject Platelet count (Plt) en_US
dc.title The impact of co-infections on the haematological profile of East African short-horn Zebu calves en_US
dc.type Article en_US

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