Severity of psychotic episodes in predicting concurrent depressive and anxiety features in acute phase schizophrenia

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dc.contributor.author Naidu, Kalai
dc.contributor.author Van Staden, C.W.
dc.contributor.author Van der Linde, Michael J. (Mike)
dc.date.accessioned 2014-08-14T09:11:45Z
dc.date.available 2014-08-14T09:11:45Z
dc.date.issued 2014-06-05
dc.description.abstract BACKGROUND: Considering that depressive and anxiety symptoms are common in schizophrenia, this study investigated whether the severity of a psychotic episode in an acute phase schizophrenia cohort is predictive of concurrent depressive and anxiety features. METHOD: Fifty one recently hospitalised patients suffering from acute phase schizophrenia participated prospectively in a cross-sectional study. The severity of the psychotic episode, the depressive features and the anxiety features were measured by the Structured Clinical Interview for Positive and Negative Syndrome Scale (SCI-PANSS), the Calgary Depression Scale for Schizophrenia (CDSS), the Hamilton Anxiety Rating Scale (HAM-A) and the Staden Schizophrenia Anxiety Rating Scale (S-SARS). The total SCI-PANSS-scores were adjusted to exclude appropriately the depression or anxiety items contained therein. To examine akathisia as potential confounder, the Barnes Akathisia Scale was also applied. The relationships were examined using linear regressions and paired t-tests were performed between lower and higher scores on the SCI-PANSS. RESULTS: A higher adjusted total SCI-PANSS-score predicted statistically significantly higher scores for depressive features on the CDSS (p < 0.0001) and for anxiety features on the HAM-A (p = 0.05) and the S-SARS (p < 0.0001). The group that scored more or equal to the median (=99) of the adjusted total SCI-PANSS, scored significantly higher (p < 0.0001) on the CDSS, the HAM-A and the S-SARS than the group scoring below it. Akathisia measured distinctly different (p < 0.0001) from both the anxiety measures. CONCLUSION: The study suggests that the severity of a psychotic episode in acute phase schizophrenia predicts the severity of concurrent depressive and anxiety features respectively. en_US
dc.description.librarian am2014 en_US
dc.description.uri http://www.biomedcentral.com/1471-244X/14/166 en_US
dc.identifier.citation Naidu, K, Van Staden, W & Van der Linder, M 2014, 'Severity of psychotic episodes in predicting concurrent depressive and anxiety features in acute phase schizophrenia', BMC Psychiatry, vol. 14, art. 166, pp. 1-7. en_US
dc.identifier.issn 1471-244X
dc.identifier.other 10.1186/1471-244X-14-166
dc.identifier.uri http://hdl.handle.net/2263/41273
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights © 2014 Naidu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_US
dc.subject Acute psychosis en_US
dc.subject Severity en_US
dc.subject Akathisia en_US
dc.subject Symptomatology en_US
dc.subject Symptoms en_US
dc.subject Schizophrenia en_US
dc.title Severity of psychotic episodes in predicting concurrent depressive and anxiety features in acute phase schizophrenia en_US
dc.type Article en_US


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