An ultrastructural analysis of platelets, erythrocytes, white blood cells, and fibrin network in systemic lupus erythematosus
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Date
Authors
Pretorius, Etheresia
Du Plooy, Jeanette Noel
Soma, Prashilla
Gasparyan, Armen Yuri
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
The study suggests that patients with systemic
lupus erythematosus (SLE) present with distinct inflammatory
ultrastructural changes such as platelets blebbing,
generation of platelet-derived microparticles, spontaneous
formation of massive fibrin network and fusion of the
erythrocytes membranes. Lupoid platelets actively interact
with other inflammatory cells, particularly with white
blood cells (WBCs), and the massive fibrin network facilitates
such an interaction. It is possible that the concerted
actions of platelets, erythrocytes and WBC, caught in the
inflammatory fibrin network, predispose to pro-thrombotic
states in patients with SLE.
Description
Keywords
Systemic lupus erythematosus, Platelet function, Erythrocytes, White blood cells, Fibrin, Electron microscopy
Sustainable Development Goals
Citation
Pretorius, E, Du Plooy, J, Soma, P & Gasparyan, AY 2014, 'An ultrastructural analysis of platelets, erythrocytes, white blood cells, and fibrin network in systemic lupus erythematosus', Rheumatology International, vol. 34, no. 7, pp. 1005-1009.