This dissertation describes the effects of tetrastarch (130/0.4) on serum colloid
osmotic pressure and thromboelastography variables in healthy pony mares.
Additional variables assessed during this study included markers of haemodilution
(PCV, TS) and serum creatinine and bile acid concentrations. Six clinically healthy Nooitgedacht pony mares were utilized in a crossover study
design. Tetrastarch (130/0.4) was administered at 10, 20 and 40 ml/kg bwt to each
mare in a random sequence with a two week washout period between each of the
treatments. Packed cell volume (PCV), plasma total solids (TS), serum colloid
osmotic pressure (COP), and platelet count were measured and thromboelastography
(TEG) was performed before treatment (baseline), immediately after infusion (time
0), and 1, 6, 12, 24, 48, and 96 h after tetrastarch infusion.
All TEG variables remained within reference range in all treatment groups.
Administration of tetrastarch at 40 ml/kg bwt resulted in a prolonged K-time at 6 h
post-infusion, and decreased maximum amplitude at 0, 1, 6, 24 and 48 h post-infusion
compared to baseline. Administration of tetrastarch increased mean COP values
above baseline in all three treatment groups, persisting to 24, 6 and 48 h after
treatment with 10, 20 and 40 ml/kg of tetrastarch respectively.
This study concluded that, although values remained within established reference
ranges, the administration of tetrastarch (130/0.4) at 40 ml/kg bwt is more likely to
induce changes in TEG variables than doses of 20 ml/kg or less. Tetrastarch increased
COP in healthy horses at all evaluated dose rates.
Dissertation (MMedVet)--University of Pretoria, 2014.