dc.contributor.author |
Tempia, Stefano
|
|
dc.contributor.author |
Walaza, Sibongile
|
|
dc.contributor.author |
Viboud, Cecile
|
|
dc.contributor.author |
Cohen, Adam L.
|
|
dc.contributor.author |
Madhi, Shabir A.
|
|
dc.contributor.author |
Venter, Marietjie
|
|
dc.contributor.author |
McAnerney, Johanna M.
|
|
dc.contributor.author |
Cohen, Cheryl
|
|
dc.date.accessioned |
2014-07-11T06:13:20Z |
|
dc.date.available |
2014-07-11T06:13:20Z |
|
dc.date.issued |
2014-05 |
|
dc.description.abstract |
BACKGROUND. There are few published data describing the mortality burden associated with influenza and respiratory
syncytial virus (RSV) infection in children in low- and middle-income countries and particularly from Africa
and settings with high prevalence of human immunodeficiency virus (HIV).
METHODS. We modeled the excess mortality attributable to influenza (seasonal and pandemic) and RSV infection
by applying Poisson regression models to monthly all-respiratory and pneumonia and influenza deaths, using
national influenza and RSV laboratory surveillance data as covariates. In addition, we estimated the seasonal influenza–
and RSV-associated deaths among HIV-infected and -uninfected children using Poisson regression models
that incorporated HIV prevalence and highly active antiretroviral therapy coverage as covariates.
RESULTS. In children less than 5 years of age, the mean annual numbers of seasonal influenza– and RSV-associated allrespiratory
deaths were 452 (8 per 100 000 person-years [PY]) and 546 (10 per 100 000 PY), respectively. Infants <1
year of age experienced higher mortality rates compared with children 1–4 years of age for both influenza (22 vs 5 per
100 000 PY) and RSV (35 vs 4 per 100 000 PY). HIV-infected compared with HIV-uninfected children <5 years of
age were at increased risk of death associated with influenza (age-adjusted relative risk [aRR], 11.5; 95% confidence
interval [CI], 9.6–12.6) and RSV (aRR, 8.1; 95% CI, 6.9–9.3) infection. In 2009, we estimated 549 (11 per 100 000 PY)
all-respiratory influenza A(H1N1)pdm09-associated deaths among children aged <5 years.
CONCLUSIONS. Our findings support increased research efforts to guide and prioritize interventions such as influenza
vaccination and HIV prevention in low- and middle-income countries with high HIV prevalence such as South
Africa. |
en_US |
dc.description.librarian |
hb2014 |
en_US |
dc.description.uri |
http://cid.oxfordjournals.org |
en_US |
dc.identifier.citation |
Tempia, S, Walaza, S, Viboud, C, Cohen, AL, Madhi, SA, Venter, M, Mcanerney, JM & Cohen, C 2014, 'Mortality associated with seasonal and pandemic influenza and respiratory syncytial virus among children <5 years of age in a high HIV prevalence setting - South Africa, 1998-2009', Clinical Infectious Diseases, vol. 58, no. 1, pp. 1241-1249. |
en_US |
dc.identifier.issn |
1058-4838 (print) |
|
dc.identifier.issn |
1537-6591 (online) |
|
dc.identifier.other |
10.1093/cid/ciu095 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/40693 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Oxford University Press |
en_US |
dc.rights |
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The definitive publisher-authenticated version of Mortality Associated With Seasonal and
Pandemic Influenza and Respiratory Syncytial
Virus Among Children <5 Years of Age in a
High HIV Prevalence Setting—South Africa,
1998–2009 in Clinical Infectious Diseases, vol.58, no.9, pp. 1241-1249, 2014. doi : 10.1093/cid/ciu095. Clinical Infectious Diseases is available online at : http://cid.oxfordjournals.org. |
en_US |
dc.subject |
Influenza |
en_US |
dc.subject |
Mortality |
en_US |
dc.subject |
Human immunodeficiency virus (HIV) |
en_US |
dc.subject |
South Africa (SA) |
en_US |
dc.subject |
Respiratory syncytial virus (RSV) |
en_US |
dc.title |
Mortality associated with seasonal and pandemic influenza and respiratory syncytial virus among children <5 years of age in a high HIV prevalence setting - South Africa, 1998-2009 |
en_US |
dc.type |
Postprint Article |
en_US |