Prevalence and pattern of brown adpose tissue distribution of 18F-FDG in patients undergoing PET-CT in a subtropical climatic zone
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Date
Authors
Perkins, Alan C.
Mshelia, Dahiru S.
Symonds, Michael E.
Sathekge, Mike Machaba
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott Williams and Wilkins
Abstract
BACKGROUND The uptake of 18F-FDG in brown adipose tissue (BAT) may have important implications in understanding the pathophysiology of BAT and obesity. Because of the thermal implications of BAT uptake of 18F-FDG, this study aimed to contribute to existing knowledge by assessing patients scanned in a subtropical environment with particular reference to ethnicity.
PATIENTS AND METHODS A retrospective study was carried out to determine the prevalence and pattern of BAT uptake in patients undergoing 18F-FDG PET-CT imaging in a PET facility located in a subtropical climatic zone. Standardized uptake values were obtained for regions of BAT uptake of 18F-FDG, and the distribution pattern was assessed according to anatomical region, sex, age, BMI and ethnicity.
RESULTS Following a reveiw of a total of 386 scans, 38 patients showed BAT uptake of 18F-FDG (9.85%), with the mass and activity of BAT being greater in women than in men (11.95 and 6.88%, respectively). BAT uptake of 18F-FDG in the neck/supraclavicular, axillary and mediastinal regions was greater in adults whose BMI was less than 18kg/m2. However, perirenal BAT activity was shown to be greater in obese individuals. The frequency of BAT uptake of 18F-FDG was 55% in winter as against 45% during summer (P<0.012). There was no statistical difference in BAT uptake between black and white patients.
CONCLUSION This study shows the pattern and prevalence of BAT in patients in a subtropical environment. Although the average seasonal temperatures are higher in a subtropical climate, a seasonal variation in BAT expression was observed, although there were no differences with respect to patient ethnicity.
Description
Keywords
Brown fat, 18F-FDG imaging, PET imaging, Subtropical climate, Brown adipose tissue (BAT)
Sustainable Development Goals
Citation
Perkins, AC, Mshelia, DS, Symonds, ME & Sathekge, MM 2013, 'Prevalence and pattern of brown adpose tissue distribution of 18F-FDG in patients undergoing PET-CT in a subtropical climatic zone', Nuclear Medicine Communications, vol. 34, no. 2, pp.168-174.