Multiple tendon ruptures in ochronosis : case report and review of prophylactic therapy

Ngcelwane, Mthunzi Victor; Mandaba, M.; Bam, T.Q.

dc.contributor.author	Ngcelwane, Mthunzi Victor
dc.contributor.author	Mandaba, M.
dc.contributor.author	Bam, T.Q.
dc.date.accessioned	2014-06-18T10:55:13Z
dc.date.available	2014-06-18T10:55:13Z
dc.date.issued	2013
dc.description.abstract	Ochronosis is dark pigmentation of connective tissue in patients with alkaptonuria. The dark pigmentation is caused by accumulation of homogentisic acid (HGA) and its metabolites in the connective tissues, due to deficiency of an enzyme that degrades HGA in the tyrosine degradation pathway. The deposition of HGA in connective tissue causes weakness of the tendon and subsequent rupture, especially the large tendons in the body. Rupture of isolated tendons has been reported in many case reports in the literature. We report on a patient with multiple sequential tendon ruptures, and review the literature to see if there is a way of preventing subsequent tendon ruptures after an initial rupture in this condition.	en_US
dc.description.librarian	am2014	en_US
dc.description.uri	http://www.charpublications.co.za/C_JournalsORTH.asp	en_US
dc.identifier.citation	Ngcelwane, MV, Mandaba, M & Bam, TQ 2013, 'Multiple tendon ruptures in ochronosis : case report and review of prophylactic therapy', SA Orthopaedic Journal, vol. 12, no. 1, pp. 55-57.	en_US
dc.identifier.issn	1681-150X
dc.identifier.uri	http://hdl.handle.net/2263/40286
dc.language.iso	en	en_US
dc.publisher	Media 24 & South African Orthopaedic Association	en_US
dc.rights	Media 24 & South African Orthopaedic Association	en_US
dc.subject	Ochronosis	en_US
dc.subject	Multiple tendon ruptures	en_US
dc.subject	Medical prophylaxis in ochronosis	en_US
dc.subject	Homogentisic acid (HGA)	en_US
dc.title	Multiple tendon ruptures in ochronosis : case report and review of prophylactic therapy	en_US
dc.type	Article	en_US