Multiple tendon ruptures in ochronosis : case report and review of prophylactic therapy
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Date
Authors
Ngcelwane, Mthunzi Victor
Mandaba, M.
Bam, T.Q.
Journal Title
Journal ISSN
Volume Title
Publisher
Media 24 & South African Orthopaedic Association
Abstract
Ochronosis is dark pigmentation of connective tissue in patients with alkaptonuria. The dark pigmentation is
caused by accumulation of homogentisic acid (HGA) and its metabolites in the connective tissues, due to deficiency
of an enzyme that degrades HGA in the tyrosine degradation pathway. The deposition of HGA in connective
tissue causes weakness of the tendon and subsequent rupture, especially the large tendons in the body.
Rupture of isolated tendons has been reported in many case reports in the literature. We report on a patient with
multiple sequential tendon ruptures, and review the literature to see if there is a way of preventing subsequent tendon
ruptures after an initial rupture in this condition.
Description
Keywords
Ochronosis, Multiple tendon ruptures, Medical prophylaxis in ochronosis, Homogentisic acid (HGA)
Sustainable Development Goals
Citation
Ngcelwane, MV, Mandaba, M & Bam, TQ 2013, 'Multiple tendon ruptures in ochronosis : case report and review of prophylactic therapy', SA Orthopaedic Journal, vol. 12, no. 1, pp. 55-57.