Cellular scaling rules for the brain of afrotherians

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dc.contributor.author Neves, Kleber
dc.contributor.author Ferreira, Fenanda M.
dc.contributor.author Tovar-Moll, Fernanda
dc.contributor.author Gravett, Nadine
dc.contributor.author Bennett, Nigel C., 1961-
dc.contributor.author Kaswera, Consolate
dc.contributor.author Gilissen, Emmanuel
dc.contributor.author Manger, Paul R.
dc.contributor.author Herculano-Houzel, Suzana
dc.date.accessioned 2014-06-04T05:37:01Z
dc.date.available 2014-06-04T05:37:01Z
dc.date.issued 2014-02
dc.description.abstract Quantitative analysis of the cellular composition of rodent, primate and eulipotyphlan brains has shown that non-neuronal scaling rules are similar across these mammalian orders that diverged about 95 million years ago, and therefore appear to be conserved in evolution, while neuronal scaling rules appear to be free to vary in evolution in a clade-specific manner. Here we analyze the cellular scaling rules that apply to the brain of afrotherians, believed to be the first clade to radiate from the common eutherian ancestor. We find that afrotherians share non-neuronal scaling rules with rodents, primates and eulipotyphlans, as well as the coordinated scaling of numbers of neurons in the cerebral cortex and cerebellum. Afrotherians share with rodents and eulipotyphlans, but not with primates, the scaling of number of neurons in the cortex and in the cerebellum as a function of the number of neurons in the rest of the brain. Afrotheria also share with rodents and eulipotyphlans the neuronal scaling rules that apply to the cerebral cortex. Afrotherians share with rodents, but not with eulipotyphlans nor primates, the neuronal scaling rules that apply to the cerebellum. Importantly, the scaling of the folding index of the cerebral cortex with the number of neurons in the cerebral cortex is not shared by either afrotherians, rodents, or primates. The sharing of some neuronal scaling rules between afrotherians and rodents, and of some additional features with eulipotyphlans and primates, raise the interesting possibility that these shared characteristics applied to the common eutherian ancestor. In turn, the clade-specific characteristics that relate to the distribution of neurons along the surface of the cerebral cortex and to its degree of gyrification suggest that these characteristics compose an evolutionarily plastic suite of features that may have defined and distinguished mammalian groups in evolution. en_US
dc.description.librarian hb2014 en_US
dc.description.uri http://www.frontiersin.org/Neuroanatomy en_US
dc.identifier.citation Neves, K, Ferreira, FM, Tovar-Moll, F, Gravett, N, Bennett, NC, Kaswera, C, Gilissen, E, Manger, PR & Herculano-Houzel, S 2014, 'Cellular scaling rules for the brain of afrotherians', Frontiers in Neuroanatomy, vol. 8, art. 5, pp. 1-13. en_US
dc.identifier.issn 1662-5129 (online)
dc.identifier.other 10.3389/neuro.05.008.2009
dc.identifier.uri http://hdl.handle.net/2263/39960
dc.language.iso en en_US
dc.publisher Frontiers Research Foundation en_US
dc.rights © 2014 Neves, Ferreira, Tovar-Moll, Gravett, Bennett, Kaswera, Gilissen, Manger and Herculano-Houzel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en_US
dc.subject Evolution en_US
dc.subject Glia-neuron ratio en_US
dc.subject Numbers of neurons en_US
dc.subject Cortical expansion en_US
dc.subject Gyrification en_US
dc.title Cellular scaling rules for the brain of afrotherians en_US
dc.type Article en_US


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