A convenient synthesis of bifunctional sulfonamide-amide derivatives was reported. Amide coupling of 4-methyl
benzoic acid 1 followed by reaction with chlorosulfonic acid produce ethyl-4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine-
1-carboxylate 4. The resulted compound on further treatment with various anilines produces the title sulfonamide-amide derivatives
5a−n. The configurations of these compounds were established by elemental analysis, IR, 1H NMR, mass spectra, and
by their preparation from the corresponding 4-methyl benzoic acid 1 and chlorosulfonic acid. All these new compounds demonstrate
significant in vitro antibacterial and antifungal activities against all bacterial and fungal strains.