Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by UP Author "Van der Watt, Mariette Elizabeth"
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Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by UP Author "Van der Watt, Mariette Elizabeth"
Now showing items 1-11 of 11
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Van der Watt, Mariette Elizabeth; Reader, Janette; Birkholtz, Lyn-Marie (Frontiers Media S.A., 2022-06-09)Plasmodium parasites have a complex life cycle that includes development in the human host as well as the Anopheles vector. Successful transmission of the parasite between its host and vector therefore requires the ...
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Dziwornu, Godwin Akpeko; Coertzen, Dina; Leshabane, Meta Kgaogelo; Korkor, Constance M.; Cloete, Cleavon K.; Njoroge, Mathew; Gibhard, Liezl; Lawrence, Nina; Reader, Janette; Van der Watt, Mariette Elizabeth; Wittlin, Sergio; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-04)A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure–activity ...
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Gibhard, Liezl; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Wong, Ho Ning; Batty, Kevin T.; Haynes, Richard K.; Wiesner, Lubbe (MDPI, 2021-12-03)Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside ...
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Leshabane, Meta Kgaogelo; Dziwornu, Godwin Akpeko; Coertzen, Dina; Reader, Janette; Moyo, Phanankosi; Van der Watt, Mariette Elizabeth; Chisanga, Kelly; Nsanzubuhoro, Consolata; Ferger, Richard; Erlank, Erica; Venter, Nelius; Koekemoer, Lizette; Chibale, Kelly; Birkholtz, Lyn-Marie (American Chemical Society, 2021-03)The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are ...
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Niemand, Jandeli; Van Biljon, Riette Andele; Van der Watt, Mariette Elizabeth; Van Heerden, Ashleigh; Reader, Janette; Van Wyk, Roelof Daniel Jacobus; Orchard, Lindsey M.; Chibale, Kelly; Llinas, Manuel; Birkholtz, Lyn-Marie (American Chemical Society, 2021-09)Please read abstract in the article.
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Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Leshabane, Meta Kgaogelo; Langeveld, Henrico; Cheuka, Peter M.; Dziwornu, Godwin Akpeko; Chibale, Kelly; Birkholtz, Lyn-Marie (Taylor and Francis, 2021)The effectiveness of current antimalarial therapies that cure patients of the pathogenic asexual blood stages is rapidly declining due to the spread of antimalarial drug resistance. This requires the development of novel ...
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Mianda, S.M.; Invernizzi, Luke; Van der Watt, Mariette Elizabeth; Reader, Janette; Moyo, Phanankosi; Birkholtz, Lyn-Marie; Maharaj, Vinesh J. (Elsevier, 2022-10)Please abstract in the article.
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Reader, Janette; Van der Watt, Mariette Elizabeth; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; Van Heerden, Ashleigh; Spillman, Natalie J.; Cowell, Anne N.; Connacher, Jessica I.; Opperman, Daniel; Orchard, Lindsey M.; Llinas, Manuel; Istvan, Eva S.; Goldberg, Daniel E.; Boyle, Grant A.; Calvo, David; Mancama, Dalu; Coetzer, Theresa L.; Winzeler, Elizabeth A.; Duffy, James; Koekemoer, Lizette L.; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marie (Nature Publishing Group, 2021-01)Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic ...
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Cheuka, Peter Mubanga; Centani, Luyanda; Arendse, Lauren B.; Fienberg, Stephen; Wambua, Lynn; Renga, Shoneeze S.; Dziwornu, Godwin Akpeko; Kumar, Malkeet; Lawrence, Nina; Taylor, Dale; Wittlin, Sergio; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-01)Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation ...
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Reader, Janette; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Theron, Anjo; Leshabane, Meta Kgaogelo; Da Rocha, Michelle; Turner, Jonathan; Garrabrant, Kathleen; Pina, Ivett; Mills, Catherine; Woster, Patrick M.; Birkholtz, Lyn-Marie (Wiley, 2022-11)Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block humanto- mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium ...
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Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie (Frontiers Media, 2022-06)Malaria elimination is dependent on the ability to target both the pathogenic and transmissible stages of the human malaria parasite, Plasmodium falciparum. These forms of the parasite are differentiated by unique developmental ...
Now showing items 1-11 of 11