Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by Subject "Epigenetics"

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H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

Connacher, Jessica I.; Josling, Gabrielle A.; Orchard, Lindsey M.; Reader, Janette; Llinas, Manuel; Birkholtz, Lyn-Marie (BMC, 2021-04)

BACKGROUND : The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional ...
New transmission-selective antimalarial agents through hit-to-lead optimization of 2-([1,1 '-Biphenyl]-4-carboxamido)benzoic acid derivatives

Reader, Janette; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Theron, Anjo; Leshabane, Meta Kgaogelo; Da Rocha, Michelle; Turner, Jonathan; Garrabrant, Kathleen; Pina, Ivett; Mills, Catherine; Woster, Patrick M.; Birkholtz, Lyn-Marie (Wiley, 2022-11)

Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block humanto- mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium ...

Now showing items 1-2 of 2

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