In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of Alzheimer disease

Show simple item record Ali, Shereen K. Hamed, Ahmed R. Soltan, Maha M. Hegazy, Usama M Elgorashi, Esam E. El-Garf, Ibrahim A. Hussein, Ahmed A. 2014-04-14T07:33:15Z 2014-04-14T07:33:15Z 2013-05-30
dc.description.abstract BACKGROUND: Egyptians recognized the healing power of herbs and used them in their medicinal formulations. Nowadays, “Attarin” drug shops and the public use mainly the Unani medicinal system for treatment of their health problems including improvement of memory and old age related diseases. Numerous medicinal plants have been described in old literature of Arabic traditional medicine for treatment of Alzheimer’s disease (AD) (or to strengthen memory). METHODS: In this study, some of these plants were evaluated against three different preliminary bioassays related to AD to explore the possible way of their bio-interaction. Twenty three selected plants were extracted with methanol and screened in vitro against acetylcholinesterase (AChE) and cycloxygenase-1 (COX-1) enzymes. In addition, anti-oxidant activity using DPPH was determined. RESULTS: Of the tested plant extracts; Adhatoda vasica and Peganum harmala showed inhibitory effect on AChE at IC50 294 μg/ml and 68 μg/ml respectively. Moreover, A. vasica interacted reversibly with the enzyme while P. harmala showed irreversible inhibition. Ferula assafoetida (IC50 3.2 μg/ml), Syzygium aromaticum (34.9 μg/ml) and Zingiber officinalis (33.6 μg/ml) showed activity against COX-1 enzyme. Potent radical scavenging activity was demonstrated by three plant extracts Terminalia chebula (EC50 2.2 μg/ml), T. arjuna (3.1 μg/ml) and Emblica officinalis (6.3 μg/ml). CONCLUSION: Interestingly, differential results have been obtained which indicate the variability of the mode of actions for the selected plants. Additionally, the reversible interaction of A. vasica against AChE and the potent activity of F. assafoetida against COX-1 make them effective, new and promising agents for treatment of AD in the future, either as total extracts or their single bioactive constituents. en
dc.description.librarian am2014 en
dc.description.librarian mn2014
dc.description.sponsorship Science and Technology Development Fund (STDF), Egypt (project number 251) en
dc.description.uri en
dc.identifier.citation Ali et al.: In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of alzheimer disease. BMC Complementary and Alternative Medicine 2013 13:121. en
dc.identifier.issn 1472-6882
dc.identifier.other 10.1186/1472-6882-13-121
dc.language.iso en en
dc.publisher BioMed Central en
dc.rights © 2013 Ali et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License en
dc.subject Egyptian herbal medicine en
dc.subject Unani medicine en
dc.subject Alzheimer’s disease en
dc.subject Anti-acetylcholinesterase en
dc.subject Anti-inflammatory en
dc.subject Anti-oxidant en
dc.subject Adhatoda vasica en
dc.subject Ferula assafoetida en
dc.subject.lcsh Alternative medicine -- South Africa en
dc.subject.lcsh Materia medica, Vegetable en
dc.subject.lcsh Medicinal plants en
dc.title In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of Alzheimer disease en
dc.type Article en

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