Novel insights into the bovine polled phenotype and horn ontogenesis in bovidae

Show simple item record Allais-Bonnet, Aurelie Grohs, Cecile Medugorac, Ivica Krebs, Stefan Djari, Anis Graf, Alexander Fritz, Sebastien Seichter, Doris Baur, Aurelia Russ, Ingolf Bouet, Stephan Rothammer, Sophie Wahlberg, Per Esquerre, Diane Hoze, Chris Boussaha, Mekki Weiss, Bernard Thepot, Dominique Fouilloux, Marie-Noelle Rossignol, Marie-Noelle Van Marle-Koster, Este Hreioarsdottir, Gunnfrıour Elın Barbey, Sarah Dozias, Dominique Cobo, Emilie Reverse, Patrick Catros, Olivier Marchand, Jean-Luc Soulas, Pascal Roy, Pierre Marquant-Leguienne, Brigitte Le Bourhis, Daniel Clement, Laetitia Salas-Cortes, Laura Venot, Eric Pannetier, Maelle Phocas, Florence Klopp, Christophe Rocha, Dominique Fouchet, Michel Journaux, Laurent Bernard-Capel, Carine Ponsart, Claire Eggen, Andre Blum, Helmut Gallard, Yves Boichard, Didier Pailhoux, Eric Capitan, Aurelien 2014-04-01T10:15:48Z 2014-04-01T10:15:48Z 2013-05-22
dc.description.abstract Despite massive research efforts, the molecular etiology of bovine polledness and the developmental pathways involved in horn ontogenesis are still poorly understood. In a recent article, we provided evidence for the existence of at least two different alleles at the Polled locus and identified candidate mutations for each of them. None of these mutations was located in known coding or regulatory regions, thus adding to the complexity of understanding the molecular basis of polledness. We confirm previous results here and exhaustively identify the causative mutation for the Celtic allele (PC) and four candidate mutations for the Friesian allele (PF). We describe a previously unreported eyelash-and-eyelid phenotype associated with regular polledness, and present unique histological and gene expression data on bovine horn bud differentiation in fetuses affected by three different horn defect syndromes, as well as in wild-type controls. We propose the ectopic expression of a lincRNA in PC/p horn buds as a probable cause of horn bud agenesis. In addition, we provide evidence for an involvement of OLIG2, FOXL2 and RXFP2 in horn bud differentiation, and draw a first link between bovine, ovine and caprine Polled loci. Our results represent a first and important step in understanding the genetic pathways and key process involved in horn bud differentiation in Bovidae. en_US
dc.description.librarian am2014 en_US
dc.description.sponsorship Apis Ge`ne ‘‘Hornout’’ and Institut National de la Recherche Agronomique-DGA ‘‘Interpolled’’ and ‘‘Hornaseq’’ grants. en_US
dc.description.uri en_US
dc.identifier.citation Allais-Bonnet A, Grohs C, Medugorac I, Krebs S, Djari A, et al. (2013) Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae. PLoS ONE 8(5): e63512. DOI: 10.1371/journal.pone.0063512 en_US
dc.identifier.issn 1935-2727
dc.identifier.other 10.1371/journal.pone.0063512
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights © 2013 Allais-Bonnet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License en_US
dc.subject Bovine polledness en_US
dc.subject Horn ontogenesis en_US
dc.subject Bovidae en_US
dc.subject Celtic allele en_US
dc.subject Alleles en_US
dc.title Novel insights into the bovine polled phenotype and horn ontogenesis in bovidae en_US
dc.type Article en_US

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