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Browsing Natural and Agricultural Sciences by UP Author "Neitz, Albert Walter Herman"
Now showing items 1-12 of 12
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Malan, Melissa; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Wiley, 2016-01)Antimicrobial peptides (AMPs) are small, cationic peptides that possess a large spectrum of bioactivities, including antimicrobial, anti-inflammatory and antioxidant activities. Several AMPs are known to inhibit ...
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Louw, Elizabeth M.; Van der Merwe, Nicolaas Albertus (Albie); Neitz, Albert Walter Herman; Maritz-Olivier, Christine (Elsevier, 2013-01)One of the principle mechanisms utilised by ticks to obtain a blood meal is the subversion of the host’s haemostatic response. This is achieved through the secretion of saliva containing anti-haemostatic proteins into ...
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Taute, Helena; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2015-09)Os and Os-C are two novel antimicrobial peptides, derived from a tick defensin, which have been shown to have a larger range of antimicrobial activity than the parent peptide, OsDef2. The aim of this study was to determine ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2019-02)Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2020-12)Type 2 diabetes mellitus (T2DM) is a multifactorial disease that requires multiple therapeutic strategies for its management. Bioactive peptides with multiple anti-diabetic targets are attractive therapeutic molecules. The ...
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Stopforth, Elaine; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2010-08)A proteomics approach was employed to identify proteins secreted into the hemolymph of Ornithodorus savignyi ticks 2 h after immune-challenge with the yeast, Candida albicans. Profiling of the proteins present in hemolymph ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2018-11)Treatment of type 2 diabetes is achieved through the inhibition of carbohydrate hydrolyzing enzymes such as α-glucosidase and α-amylase. The present study was conducted to identify novel α-glucosidase inhibitory peptides ...
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Cheng, Paul H.; Mans, Ben J. (Barend Johannes); Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2010-11)Savicalin, is a lipocalin found in the hemocytes of the soft tick, Ornithodoros savignyi. It could be assigned to the tick lipocalin family based on BLAST analysis. Savicalin is the first non-salivary gland lipocalin ...
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Prinsloo, Lezaan; Naidoo, Alex; Serem, June Cheptoo; Taute, Helena; Sayed, Yasien; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Wiley, 2013-05)Tick defensins may serve as templates for the development of multifunctional peptides. The purpose of this study was to evaluate shorter peptides derived from tick defensin isoform 2 (OsDef2) in terms of their antibacterial, ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Wiley, 2018-02)Bioactive peptides are emerging as promising class of drugs that could serve as α-glucosidase inhibitors for the treatment of type 2 diabetes. This article identifies structural and physicochemical requirements for the ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Bentham Science, 2019-07)BACKGROUND : Peptide-based therapeutics offer a unique avenue for the development of novel agents for the treatment of diabetes mellitus including α-glucosidase inhibitors. The peptide, SQSPA, was reported to possess to α ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2019-06)In silico analysis was used to evaluate storage proteins from plant tubers as potential precursors of bioactive peptides after simulated gastrointestinal digestion. Proteins derived from potato (patatins), sweet potato ...
Now showing items 1-12 of 12