Browsing Natural and Agricultural Sciences by UP Author "Abrie, Clarissa"

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Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases

Morahan, Belinda J.; Abrie, Clarissa; Al-Hasani, Keith; Batty, Mitchell B.; Corey, Victoria; Cowell, Anne N.; Niemand, Jandeli; Winzeler, Elizabeth A.; Birkholtz, Lyn-Marie; Doerig, Christian; Garcia-Bustos, Jose F. (Nature Research, 2020-11)

Mitosis has been validated by numerous anti-cancer drugs as being a druggable process, and selective inhibition of parasite proliferation provides an obvious opportunity for therapeutic intervention against malaria. ...
Inducing controlled cell cycle arrest and re-entry during asexual proliferation of plasmodium falciparum malaria parasites

Van Biljon, Riette Andele; Niemand, Jandeli; Clark, Katherine; Verlinden, Bianca K.; Abrie, Clarissa; Von Gruning, Hilde; Smidt, Werner; Smit, Annel; Reader, Janette; Painter, Heather; Llinas, Manuel; Doerig, Christian; Birkholtz, Lyn-Marie (Nature Publishing Group, 2018-11-08)

The life cycle of the malaria parasite Plasmodium falciparum is tightly regulated, oscillating between stages of intense proliferation and quiescence. Cyclic 48-hour asexual replication of Plasmodium is markedly different ...

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