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Browsing Natural and Agricultural Sciences by Supervisor "Niemand, Jandeli"
Now showing items 1-9 of 9
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(University of Pretoria, 2022)Despite efforts to reduce the global spread and severity of malaria infection, resistance towards current frontline antimalarials has halted malaria elimination progress. Thus, malaria parasite biology should be continually ...
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(University of Pretoria, 2020)Late-stage gametocytes of P. falciparum parasites are responsible for the ongoing human-to-mosquito transmission of malaria disease. To block transmission, novel gametocytocidal compounds are required. It is thus important ...
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(University of Pretoria, 2017)Functional genomic tools can be used to interrogate unique features of parasite biology that could be marked for future intervention strategies. One such unique biological feature is the atypical cell cycle of the Plasmodium ...
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(University of Pretoria, 2022)The elimination of the life-threatening malaria disease caused by Plasmodium falciparum parasites remains a global health challenge. It is imperative that novel biological targets are identified not only in the pathogenic ...
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(University of Pretoria, 2018)The Plasmodium falciparum parasite is the causative agent of the most severe form of malaria. The increase in resistance against the majority of antimalarial compounds underpins the need for the development of new antimalarial ...
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(University of Pretoria, 2018)The success achieved in controlling malaria in recent years [1, 2], has caused a focal shift to elimination of the disease, with renewed interest in the discovery of novel chemotherapeutics with unique modes of action ...
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(University of Pretoria, 2021)Severe malaria is caused by the Plasmodium falciparum protozoan. This malaria-causing parasite has a complex life cycle including a proliferative asexual stage and a terminally differentiated gametocyte stage, which is ...
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(University of Pretoria, 2019)The Plasmodium falciparum parasite, the major causative agent of malaria on the African continent, has evolved numerous cellular adaptations to effectively propagate its species. The parasite can proliferate asexually, ...
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(University of Pretoria, 2018)Malaria remains a leading health problem with an estimated 445 000 deaths occurring in 2016 of which the majority of deaths occurred in Africa. Currently, the World Health Organization recommends artemisinin-based combination ...
Now showing items 1-9 of 9