In vitro determination of the anti-aging potential of four southern African medicinal plants

Show simple item record Ndlovu, Gugulethu Fouche, Gerda Tselanyane, Malefa Cordier, Werner Steenkamp, Vanessa 2014-03-07T09:38:57Z 2014-03-07T09:38:57Z 2013-11-05
dc.description.abstract BACKGROUND: Aging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four southern African medicinal plants; Clerodendrum glabrum, Schotia brachypetala, Psychotria capensis and Peltophorum africanum, were investigated to assess their anti-aging properties. METHODS: Anti-elastase, anti-collagenase and anti-hyaluronidase activities of twenty-eight samples, consisting of methanol and ethyl acetate extracts of the four plants, were determined using spectrophotometric methods. Radical scavenging activity was determined by the ability of the plant extracts to scavenge the ABTS•+ radical. RESULTS: The majority of the samples in the anti-elastase assay and nine in the anti-collagenase assay showed more than 80% inhibition. The ethyl acetate extract of S. brachypetala bark and leaves of P. capensis inhibited elastase activity by more than 90%. The methanol extract of S. brachypetala bark contained the highest anti-hyaluronidase activity (75.13 ± 7.49%) whilst the ethyl acetate extract of P. africanum bark exhibited the highest antioxidant activity (IC50: 1.99 ± 0.23 μg/ml). CONCLUSION: The free radical scavenging activity and enzyme inhibitory activity of the plant extracts investigated suggests that they can help restore skin elasticity and thereby slow the wrinkling process. P. africanum was the plant with the most promising activity and will be subjected to further testing and isolation of the active compound/s. en_US
dc.description.librarian am2014 en_US
dc.description.sponsorship The Department of Science and Technology (South Africa), The Council for Scientific and Industrial Research, the University of Pretoria and The European Union (AgroCos FP7 project). en_US
dc.description.uri en_US
dc.identifier.citation Ndlovu et al.: In vitro determination of the anti-aging potential of four southern African medicinal plants. BMC Complementary and Alternative Medicine 2013 13:304. en_US
dc.identifier.issn 1472-6882
dc.identifier.other 10.1186/1472-6882-13-304
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights © 2013 Ndlovu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License en_US
dc.subject Anti-aging en_US
dc.subject Anti-collagenase en_US
dc.subject Anti-elastase en_US
dc.subject Anti-hyaluronidase en_US
dc.subject Anti-oxidant en_US
dc.subject Medicinal plants en_US
dc.title In vitro determination of the anti-aging potential of four southern African medicinal plants en_US
dc.type Article en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record