Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows

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dc.contributor.author Esposito, Giulia
dc.contributor.author Irons, Pete Charles
dc.contributor.author Webb, E.C. (Edward Cottington)
dc.contributor.author Chapwanya, Aspinas
dc.date.accessioned 2014-02-27T06:44:13Z
dc.date.available 2014-02-27T06:44:13Z
dc.date.issued 2014-01
dc.description.abstract The biological cycles of milk production and reproduction determine dairying profitability thus making management decisions dynamic and time-dependent. Diseases also negatively impact on net earnings of a dairy enterprise. Transition cows in particular face the challenge of negative energy balance (NEB) and/or disproportional energy metabolism (fatty liver, ketosis, subacute, acute ruminal acidosis); disturbed mineral utilization (milk fever, sub-clinical hypocalcemia); and perturbed immune function (retained placenta, metritis, mastitis). Consequently NEB and reduced dry matter intake are aggravated. The combined effects of all these challenges are reduced fertility and milk production resulting in diminishing profits. Risk factors such as NEB, inflammation and impairment of the immune response are highly cause-and-effect related. Thus, managing cows during the transition period should be geared toward reducing NEB or feeding specially formulated diets to improve immunity. Given that all cows experience a reduced feed intake and body condition, infection and inflammation of the uterus after calving, there is a need for further research on the immunology of transition dairy cows. Integrative approaches at the molecular, cellular and animal level may unravel the complex interactions between disturbed metabolism and immune function that predispose cows to periparturient diseases. en
dc.description.librarian hb2014 en
dc.description.librarian ab2014
dc.description.sponsorship Institute of Food, Nutrition and Wellbeing (IFNuW) from the University of Pretoria, South Africa. en
dc.description.uri http://www.elsevier.com/locate/anireprosci en
dc.identifier.citation Esposito, G, Irons, PC, Webb, EC & Chapwanya, A 2014, ' Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows', Animal Reproduction Science, vol. 144, no. 3-4, pp. 60-71. en
dc.identifier.issn 0378-4320 (print)
dc.identifier.issn 1873-2232 (online)
dc.identifier.other 10.1016/j.anireprosci.2013.11.007
dc.identifier.other 6603165622
dc.identifier.other O-6401-2014
dc.identifier.uri http://hdl.handle.net/2263/36828
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2013 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Animal Reproduction Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Animal Reproduction Science, vol.144, no. 3-4, pp.60-71. 2014. doi : 10.1016/j.anireprosci.2013.11.007 en
dc.subject PUFA en
dc.subject Metritis en
dc.subject Endometritis en
dc.subject Transition cows en
dc.subject Negative energy balance (NEB) en
dc.subject UCTD en_US
dc.subject.lcsh Cows en
dc.subject.lcsh Metabolic disorders in animals en
dc.subject.lcsh Bioenergetics en
dc.subject.lcsh Cattle -- Diseases en
dc.subject.lcsh Dairy cattle en
dc.title Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows en
dc.type Postprint Article en


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