The efficacy of Advantix to prevent transmission of Ehrlichia canis to dogs by Rhipicephalus sanguineus ticks

Show simple item record Fourie, Josephus J. Luus, Herman Gerhardus Stanneck, Dorothee Jongejan, Frans 2014-02-12T10:24:19Z 2014-02-12T10:24:19Z 2013-10-21
dc.description.abstract The capacity of a topical combination of imidacloprid and permethrin (Advantix) to prevent transmission of Ehrlichia canis was studied in two groups of six dogs. One group served as controls, whereas the other group was treated. All dogs were exposed to E. canis-infected Rhipicephalus sanguineus ticks on Days 7, 14, 21 and Day 28 post acaricidal treatment. The adult R. sanguineus ticks were released into the individual kennels of the dogs to simulate natural tick exposure. In situ tick counts were conducted on Day 9, 16 and 23 and any remaining ticks were counted and removed on Day 30. The efficacy of the acaricidal treatment against R. sanguineus ranged between 96.1% and 98.9% at 48 h post-application and lasted up to 4 weeks. Four out of six control dogs became infected with E. canis, as demonstrated by the presence of specific E. canis antibodies and the detection by PCR of E. canis DNA in blood samples. These dogs became thrombocytopenic and displayed fever and were consecutively rescue-treated by doxycycline. None of the six treated dogs became infected with E. canis, as confirmed by the lack of specific antibodies and absence of E. canis DNA in blood samples. Advantix prevented transmission of E. canis and provided protection against monocytic ehrlichiosis for 4 weeks post acaricidal treatment. en
dc.description.abstract La capacite´ d’une association locale d’imidaclopride et perme´thrine (Advantix) pour pre´venir la transmission d’Ehrlichia canis a e´te´ e´tudie´e dans deux groupes de six chiens. Un groupe a servi de te´moin, tandis que l’autre groupe a e´te´ traite´. Tous les chiens ont e´te´ expose´s a` des tiques Rhipicephalus sanguineus infecte´es par E. canis aux jours 7, 14, 21 et 28 jours apre`s traitement acaricide. Les R. sanguineus adultes ont e´te´ laˆche´s dans les niches individuelles des chiens pour simuler une exposition naturelles aux tiques. Des comptages de tiques in situ ont e´te´ mene´s aux jours 9, 16 et 23 et les tiques restantes ont e´te´ compte´es et enleve´es au jour 30. L’efficacite´ du traitement acaricide contre R. sanguineus a varie´ entre 96,1 % et 98,9 % a` 48 h apre`s l’application et a dure´ jusqu’a` quatre semaines. Quatre des six chiens te´moins ont e´te´ infecte´s avec E. canis, comme en te´moigne la pre´sence d’anticorps spe´cifiques contre E. canis et la de´tection par PCR d’ADN d’E. canis dans les e´chantillons de sang. Ces chiens sont devenus thrombocytope´nique et fie´vreux et ont e´te´ conse´cutivement traite´s jusqu’a` gue´rison par la doxycycline. Aucun des six chiens traite´s n’a e´te´ infecte´ par E. canis, comme le confirme l’absence d’anticorps spe´cifiques et d’ADN d’E. canis dans les e´chantillons de sang. Advantix a empeˆche´ la transmission d’E. canis et a fourni une protection contre l’ehrlichiose monocytaire pendant quatre semaines apre`s le traitement acaricide. en
dc.description.librarian am2014 en
dc.description.librarian ab2014
dc.description.uri en
dc.identifier.citation Fourie JJ, Luus HG, Stanneck D & Jongejan F 2013, 'The efficacy of Advantix to prevent transmission of Ehrlichia canis to dogs by Rhipicephalus sanguineus ticks', Parasite, vol. 20, no. 36, pp. 1-7. en
dc.identifier.issn 1776-1042 (online)
dc.identifier.other 10.1051/parasite/2013037
dc.language.iso en en
dc.publisher EDP Sciences en
dc.relation.requires Adobe Acrobat Reader en
dc.rights © J. J. Fourie et al., published by EDP Sciences, 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.subject Imidacloprid en
dc.subject Permethrin en
dc.subject Ehrlichia canis en
dc.subject Rhipicephalus sanguineus en
dc.subject Ehrlichiosis en
dc.subject Transmission en
dc.subject.lcsh Dogs -- Diseases en
dc.subject.lcsh Ehrlichiosis en
dc.subject.lcsh Ticks en
dc.subject.lcsh Brown dog tick en
dc.title The efficacy of Advantix to prevent transmission of Ehrlichia canis to dogs by Rhipicephalus sanguineus ticks en
dc.type Article en

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