The hippocampus of the eastern rock sengi.cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis

Show simple item record Slomianka, Lutz Drenth, Tanja Cavegn, Nicole Menges, Dominik Lazic, Stanley E. Phalanndwa, Mashudu V. Chimimba, Christian Timothy Amrein, Irmgard 2014-01-30T08:41:52Z 2014-01-30T08:41:52Z 2013-10
dc.description.abstract The brains of sengis (elephant shrews, order Macroscelidae) have long been known to contain a hippocampus that in terms of allometric progression indices is larger than that of most primates and equal in size to that of humans. In this report, we provide descriptions of hippocampal cytoarchitecture in the eastern rock sengi (Elephantulusmyurus), of the distributions of hippocampal calretinin,calbindin,parvalbumin,and somatostatin,of principal neuron numbers,and of cell numbers related to proliferation and neuronal differentiation in adult hippocampal neurogenesis.Sengi hippocampal cytoarchitecture is an amalgamation of characters that are found in CA1 of,e.g.,guinea pig and rabbits and in CA3 and dentate gyrus of primates.Correspondence analysis of total cell numbers and quantitative relations between principal cell populations relate this sengi to macaque monkeys and domestic pigs,and distinguish the sengi from distinct patterns of relations found in humans,dogs,and murine rodents.Calretinin and calbindin are present in some cell populations that also express these proteins in other species,e.g.,interneurons at the stratum oriens/alveus border or temporal hilar mossy cells,but neurons expressing these markers are often scarce or absent in other layers.The distributions of parvalbumin and somatostatin resemble those in other species.Normalized numbers of PCNA+ proliferating cells and doublecortin-positive (DCX+) differentiating cell s of neuronal lineage fall with in the overall ranges of muridrodents,but differed from three murid species captured in the same habitat in that fewer DCX+ cells relative to PCNA+ were observed.The largeand well-differentiated sengi hippocampusis not accompanied by correspondingly sized cortical and subcortical limbic areas that are the main hippocampal sources of afferents and targets of efferents.This points to intrinsic hippocampal information processing as the selective advantage of the large sengi hippocampus. en
dc.description.librarian hb2014 en
dc.description.librarian ab2014
dc.description.uri en
dc.identifier.citation Slomianka, L, Drenth, T, Cavegn, N, Menges, D, Lazic, SE, Phalanndwa, M, Chimimba, CT & Amrein, I 2013, 'The hippocampus of the eastern rock sengi. cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis', Frontiers in Neuroanatomy, vol. 7, # 34, pp. 1-20. en
dc.identifier.issn 1662-5129 (online)
dc.identifier.other 10.3389/fnana.2013.00034
dc.language.iso en en
dc.publisher Frontiers Research Foundation en
dc.rights © 2013 Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.subject Macroscelididae en
dc.subject Comparative neuroanatomy en
dc.subject Calcium-bindingproteins en
dc.subject Somatostatin en
dc.subject Correspondence analysis en
dc.subject Dentate gyrus en
dc.subject Proliferation en
dc.subject Neuronal differentiation en
dc.subject.lcsh Elephant shrews en
dc.subject.lcsh Macroscelidea en
dc.subject.lcsh Hippocampus (Brain) en
dc.subject.lcsh Developmental neurobiology en
dc.title The hippocampus of the eastern rock sengi.cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis en
dc.type Article en

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