Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011

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dc.contributor.author Gumede, Nicksy
dc.contributor.author Lentsoane, Olivia
dc.contributor.author Burns, Cara C.
dc.contributor.author Pallansch, Mark
dc.contributor.author de Gourville, Esther
dc.contributor.author Yogolelo, Riziki
dc.contributor.author Muyembe-Tamfum, Jean Jacques
dc.contributor.author Puren, Adrian
dc.contributor.author Schoub, Barry D.
dc.contributor.author Venter, Marietjie
dc.date.accessioned 2014-01-27T08:34:32Z
dc.date.available 2014-01-27T08:34:32Z
dc.date.issued 2013-10
dc.description.abstract Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004–2011 were characterized and found to be vaccine- derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5% in the viral protein 1 capsid region of the viral genome relative to the Sabin vaccine strain. Genetic analysis identified at least 7 circulating lineages localized to specific geographic regions. Multiple independent events of VDPV2 emergence occurred throughout DRC during this 7-year period. During 2010–2011, VDPV2 circulation in eastern DRC occurred in an area distinct from that of wild poliovirus circulation, whereas VDPV2 circulation in the southwestern part of DRC (in Kasai Occidental) occurred within the larger region of wild poliovirus circulation. en_US
dc.description.librarian am2014 en_US
dc.description.sponsorship This work was supported in part by a grant from the Poliomyelitis Research Fund and WHO. en_US
dc.description.uri http://www.cdc.gov/eid en_US
dc.identifier.citation Gumede, N, Lentsoane, O, Burns, CC, Pallansch, M, de Gourville, E, Yogolelo, R, Muyembe-Tamfum, JJ, Puren, A, Schoub, BD & Venter, M 2013, 'Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011', Emerging Infectious Diseases, vol. 19, no. 10, pp. 1583-1589. en_US
dc.identifier.issn 1080-6040 (print)
dc.identifier.issn 1080-6059 (online)
dc.identifier.other 10.3201/eid1910.130028
dc.identifier.uri http://hdl.handle.net/2263/33114
dc.language.iso en en_US
dc.publisher Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention en_US
dc.relation.ispartofseries Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011 en_US
dc.rights Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention en_US
dc.subject Polioviruses en_US
dc.subject Democratic Republic of Congo (DRC), 2004–2011 en_US
dc.subject Sabin vaccine strain en_US
dc.title Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011 en_US
dc.type Article en_US


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