Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011
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Date
Authors
Gumede, Nicksy
Lentsoane, Olivia
Burns, Cara C.
Pallansch, Mark
de Gourville, Esther
Yogolelo, Riziki
Muyembe-Tamfum, Jean Jacques
Puren, Adrian
Schoub, Barry D.
Venter, Marietjie
Journal Title
Journal ISSN
Volume Title
Publisher
Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention
Abstract
Polioviruses isolated from 70 acute flaccid paralysis
patients from the Democratic Republic of Congo (DRC)
during 2004–2011 were characterized and found to be vaccine-
derived type 2 polioviruses (VDPV2s). Partial genomic
sequencing of the isolates revealed nucleotide sequence divergence
of up to 3.5% in the viral protein 1 capsid region of
the viral genome relative to the Sabin vaccine strain. Genetic
analysis identified at least 7 circulating lineages localized
to specific geographic regions. Multiple independent events
of VDPV2 emergence occurred throughout DRC during
this 7-year period. During 2010–2011, VDPV2 circulation in
eastern DRC occurred in an area distinct from that of wild
poliovirus circulation, whereas VDPV2 circulation in the
southwestern part of DRC (in Kasai Occidental) occurred
within the larger region of wild poliovirus circulation.
Description
Keywords
Polioviruses, Democratic Republic of Congo (DRC), 2004–2011, Sabin vaccine strain
Sustainable Development Goals
Citation
Gumede, N, Lentsoane, O, Burns, CC, Pallansch, M, de Gourville, E, Yogolelo, R, Muyembe-Tamfum, JJ, Puren, A, Schoub, BD & Venter, M 2013, 'Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011', Emerging Infectious Diseases, vol. 19, no. 10, pp. 1583-1589.