Currently, the Lyssavirus genus is composed of four serotypes and the ungrouped European bat lyssaviruses (EBL). Using previously described PCR amplification and direct sequencing methods, the N
genes of 70 representative lyssaviruses collected from 40 different countries were examined. From the
results, a phylogenetic tree with six branches (genotypes) was constructed: genotypes 1-4 correlated
with the classification of serotypes 1-4 and in addition EBL 1 and EBL 2 were identified as two further
genotypes (5 and 6). Analysis of the 51 rabies (genotype 1) viruses in the study identified nine distinct
groups which could be correlated with their geographical origins.
A comparison of the six genotypes with four principal Vesiculovirus serotypes showed that their relationship
was closer than that of even the two most closely related Vesiculovirus serotypes.
Antigenic site sequences of isolates from vaccine/treatment failures were similar to vaccine and field
strains, suggesting that failures were not due to genetic variation at the N protein level.
The articles have been scanned in colour with a HP Scanjet 5590; 600dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.
Mileji, Gift(University of Pretoria. Faculty of Law. Centre for Human Rights, 2011-10-31)
After the Cold war, most African countries have strived to be democratic States by accommodating the idea of liberal democracy. Although these countries adopt this kind of system of governance, most of them do not adhere ...
Hayes, Vanessa M.; Bornman, Maria S. (Riana)(American Society of Clinical Oncology, 2017-03-21)
Prostate cancer (PCa) is the most common cancer
diagnosis in men from economically stable countries
and is a leading cause of cancer-related
death.1 However, the population with the highest
reported incidence and ...