dc.description.abstract |
Data on influenza epidemiology in HIV-infected persons
are limited, particularly for sub-Saharan Africa, where HIV
infection is widespread. We tested respiratory and blood
samples from patients with acute lower respiratory tract infections
hospitalized in South Africa during 2009–2011 for
viral and pneumococcal infections. Influenza was identified
in 9% (1,056/11,925) of patients enrolled; among influenza
case-patients, 358 (44%) of the 819 who were tested were
infected with HIV. Influenza-associated acute lower respiratory
tract infection incidence was 4–8 times greater for
HIV-infected (186–228/100,000) than for HIV-uninfected
persons (26–54/100,000). Furthermore, multivariable analysis
showed HIV-infected patients were more likely to have
pneumococcal co-infection; to be infected with influenza
type B compared with type A; to be hospitalized for 2–7
days or >7 days; and to die from their illness. These findings
indicate that HIV-infected persons are at greater risk
for severe illnesses related to influenza and thus should be
prioritized for influenza vaccination. |
en_US |
dc.description.sponsorship |
The National Institute for
Communicable Diseases of the National Health Laboratory Services
and was supported in part by Preparedness and Response to Avian and Pandemic Influenza in South Africa funds from the
US Centers for Disease Control and Prevention, Atlanta, Georgia,
USA (Cooperative Agreement No. U51/IP000155-04). |
en_US |
dc.identifier.citation |
Cohen, C, Moyes, J, Tempia, S, Groom, M, Walaza, S, Pretorius, M, Dawood, H, Chhagan, M, Haffejee, S, Variava, E, Kahn, K, Tshangela, A, Von Gottberg, A, Wolter, N, Cohen, AL, Kgokong, B, Venter, M & Madhi, SA 2013 , 'Severe influenza-associated respiratory infection in high HIV prevalence setting, South Africa, 2009-2011', Emerging Infectious Diseases, vol. 19, no. 11, pp. 1766-1774. |
en_US |