From the detection of the first HIV / AIDS case in Cameroon, the government's action has been swift in addressing the situation through defined policies. Although the initial stages were fraught with problems and proved wary, more policies were adopted against the background of instituting a well defined programme and institutional framework to control the pandemic. This article identifies HIV / AIDS strategies in Cameroon from a policy perspective, as well as legal considerations, with the aid of judicial experience elsewhere in Africa, most particularly, the Southern African Development Community (SADC) region. It catalogues and examines some of the major challenges confronting or likely to confront HIV / AIDS policies in Cameroon. In as much as the collaborative involvement of various actors - public, private and the civil society - is necessary to boost the implementation of national strategies, collaborative research, accountability and an appropriate legal framework, amongst others, are vital to give meaningful impetus to control HIV / AIDS in Cameroon.