Associated syndromes and other genetic variations at a South African cleft lip and palate clinic
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Date
Authors
Van den Berg, Hester J.S.
Du Plessis, Susanna M.
Butow, Kurt-Wilhelm
Honey, Engela M.
Journal Title
Journal ISSN
Volume Title
Publisher
AOSIS Open Journals
Abstract
A retrospective study was done of data on all patients registered at one of the largest cleft lip and palate clinics in South Africa (n = 3174). The associated syndromes and other genetic variations [(abbreviation:) ASGV] found in the population of persons suffering from facial cleft deformities (FCD) were analysed. 832 (26.2%) cleft lip and/ or palate patients presented with ASGV. Fifty-seven different types of syndromes were recorded of which the Fairbaim-Robin appearance (FRA) (or Pierre Robin sequence) 169 (5.3%), the Demarque-van der Woude syndrome 40 (1.3%), and the holoprosencephaly sequence cases 32 (1.0%) were the three most common ones. The three most common genetic variations found in the non-syndromic patients, were heart involvement 53(1.7%), club foot 42 (1.3%) and various eye problems 39 (1.2%). The main facial cleft deformity, namely the cleft lip, alveolus and palate (CLAP), was found in 26.2% o f the ASGV-group. This particular cleft deformity was recorded at 39.7% in the FCD clinic. On the other hand, the hard and soft palate cleft (hPsP) group was found in 32.9% of patients who also had ASGV; in the total group o f patients registered at the clinic, it accounted for only 16.6%. This means that ASGV occur less commonly in the CLAP group of patients, than in the hPsP group of patients.
Description
Keywords
Facial cleft deformity, Syndromes, Genetic variations, Cleft lip and/or palate (CL/P), Cleft lip, alveolus and palate (CLAP)
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Citation
Van den Berg, HJS, Du Plessis, SM, Butow, K-W & Honey, EM 2009, 'Associated syndromes and other genetic variations at a South African cleft lip and palate clinic', Curationis, vol. 32, no. 2, pp. 53-58.