The tiger genome and comparative analysis with lion and snow leopard genomes

Show simple item record Cho, Yun Sung Hu, Li Hou, Haolong Lee, Hang Xu, Jiaohui Kwon, Soowhan Oh, Sukhun Kim, Hak-Min Jho, Sungwoong Kim, Sangsoo Shin, Young-Ah Kim, Byung Chul Kim, Hyunmin Kim, Chang-uk Luo, Shu-Jin Johnson, Warren E. Koepfli, Klaus-Peter Schmidt-Küntzel, Anne Turner, Jason A. Marker, Laurie Harper, Cindy Kim Miller, Susan M. Jacobs, Wilhelm Bertola, Laura D. Kim, Tae Hyung Lee, Sunghoon Zhou, Qian Jung, Hyun-Ju Xu, Xiao Gadhvi, Priyvrat Xu, Pengwei Xiong, Yingqi Luo, Yadan Pan, Shengkai Gou, Caiyun Chu, Xiuhui Zhang, Jilin Liu, Sanyang He, Jing Chen, Ying Yang, Linfeng Yang, Yulan He, Jiaju Liu, Sha Wang, Junyi Kim, Chul Hong Kwak, Hwanjong Kim, Jong-Soo Hwang, Seungwoo Ko, Junsu Kim, Chang-Bae Kim, Sangtae Bayarlkhagva, Damdin Paek, Woon Kee Kim, Seong-Jin O’Brien, Stephen J. Wang, Jun Bhak, Jong 2013-11-22T10:50:38Z 2013-11-22T10:50:38Z 2013-09
dc.description.abstract Tigers and their close relatives (Panthera) are some of the world’s most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats’ hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met394Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G4A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species. en
dc.description.librarian hb2013 en
dc.description.librarian ab2013
dc.description.uri en
dc.identifier.citation Cho, YS, Hu, L, Hou, H, Lee, H, Xu, J, Kwon, S, Oh, S, Kim, H-M, Jho, S, Kim, S, Shin, Y-A, Kim, BC, Kim, H, Kim, C-U, Luo, S-J, Johnson, WE, Koepfli, K-P, Schmidt-Küntzel, A, Turner, JA, Marker, L, Harper, C, Miller, SM, Jacobs, W, Bertola, LD, Kim, TH, Lee, S, Zhou, Q, Jung, H-J, Xu, X, Gadhvi, P, Xu, P, Xiong, Y, Luo, Y, Pan, S, Gou, C, Chu, X, Zhang, J, Liu, S, He, J, Chen, Y, Yang, L, Yang, Y, He, J, L, Liu, S, Wang, J, Kim, CH, Kwak, H, Kim, J-S, Hwang, S, Ko, J, Kim, C-B, Kim, S, Bayarlkhagva, D, Paek, WK, Kim, S-J, O'Brien, SJ, Wang, J & Bhak, J 2013, 'The tiger genome and comparative analysis with lion and snow leopard genomes', Nature Communications, vol. 4, article no. 2433, pp. 1-7. en
dc.identifier.issn 2041-1723 (online)
dc.identifier.other 10.1038/ncomms3433
dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.rights © 2013 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. en
dc.subject Tiger genome en
dc.subject Comparative analysis en
dc.subject Snow leopards en
dc.subject.lcsh Panthera en
dc.subject.lcsh Tiger (Panthera tigris) en
dc.subject.lcsh Genomes en
dc.subject.lcsh Endangered species en
dc.subject.lcsh Lions en
dc.title The tiger genome and comparative analysis with lion and snow leopard genomes en
dc.type Article en

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