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Browsing Theses and Dissertations (Medical Microbiology) by Title
Now showing items 1-20 of 29
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(University of Pretoria, 2016)Polymyxins have previously been described to have activity against M. tuberculosis (M. tb), but further research was abandoned due to systemic toxicity concerns to achieve the required MIC. Colistin methanesulfonate (CMS), ...
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(University of Pretoria, 2023)Antimicrobial resistance in Mycobacterium tuberculosis and Neisseria gonorrhoeae is emerging globally. Due to the limited treatment options, the World Health Organization has designated M. tuberculosis and N. gonorrhoeae ...
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(University of Pretoria, 2015)Tuberculosis (TB) is a major cause of death worldwide, especially in Asia and Africa. Genotyping methods such as insertion sequence 6110-restriction fragment length polymorphism (IS6110-RFLP), spoligotyping and mycobacterial ...
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(University of Pretoria, 2012-10-01)Multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR-TB) is a serious problem in South Africa. Standardised and accurate drug susceptibility testing for first-line and second-line anti-TB drugs are ...
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(University of Pretoria, 2014)Tuberculosis (TB) remains a major global health problem. In 2012, an estimated 8.6 million people developed TB and 1.3 million died from the disease (including 320 000 deaths among HIV-positive people). All countries are ...
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(University of Pretoria, 2013-04-18)Sexually transmitted infections (STIs) are a major cause of acute illnesses, infertility, long term disability and death with far reaching health, social and economic consequences. Trichomonas vaginalis is the causative ...
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(University of Pretoria, 2012-08-08)Ureaplasma spp colonize the lower genital tract in many healthy men, yet can also cause urethritis and infertility. Since Ureaplasma spp are frequently isolated from the normal urogenital tract, it has been suggested ...
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(University of Pretoria, 2012-08-14)Klebsiella pneumoniae is an important nosocomial pathogen that has the potential to cause severe morbidity and mortality, particularly in intensive care units, as well as in medical and surgical wards. In recent years, ...
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Evaluation of a radiometrically-determined regrowth model for the study of anti-tuberculosis drugs (University of Pretoria, 1999)Background: A post-exposure regrowth model utilizing the well-tried Bactec radiometric system, which would simulate in vivo situations at the site of invasive disease, was developed to measure drug activity against multiplying ...
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(University of Pretoria, 2016)Background. In recent years, there has been an alarming increase in cases of multidrug-resistant tuberculosis (MDR-TB), and also extensively drug-resistant tuberculosis (XDR-TB). The emergence of these forms of tuberculosis ...
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(University of Pretoria, 2020)Tuberculosis (TB) is one of the top ten leading causes of death worldwide with millions of new TB cases reported every year. Understanding the genetic diversity of Mycobacterium tuberculosis (M. tuberculosis) is very ...
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(University of Pretoria, 2014)Staphylococcus aureus (S. aureus) is one of the leading causes of human diseases in hospital and community settings. Methicillin resistant Staphylococcus aureus (MRSA) has emerged as a significant problem worldwide, resisting ...
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Genetic relatedness of methicillin resistant Staphylococcus aureus isolates from Steve Biko hospital (University of Pretoria, 2013-04-18)Methicillin resistant Staphylococcus aureus (MRSA) causes severe infections in humans. An estimated two billion people carry S. aureus worldwide, of which fifty-three million harbour MRSA strains. The ability of MRSA to ...
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(University of Pretoria, 2012-12-14)Every year close to 9 million people contract tuberculosis (TB) and approximately 2 million die from the disease. The highest number of TB cases is in Asia while Africa has the highest incidence rates due to high rates ...
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(University of Pretoria, 2019)future, more robust or higher-resolution genomic typing tools, such as target Next Generation Sequencing (t-NGS) or metagenomic analysis are recommended to improve our understanding of the complexity of infections and for ...
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(University of Pretoria, 2023)An increasing number of linezolid resistant (LZR), multidrug-resistant (MDR) Staphylococcus capitis infections have been observed in private hospitals in the greater Gauteng area since 2014. The aim of this study was to ...
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(University of Pretoria, 2015)The global control of tuberculosis (TB) is currently hindered by the low sensitivity of microscopy and the prolonged time-to-result of culture. Recent technical progress has improved both diagnostic accuracy and turnaround, ...
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(University of Pretoria, 2004)Extended-spectrum beta-lactamases (ESBLs) in Pseudomonas aeruginosa tend to be geographically scattered, such as GES-2, which partially compromises the efficacy of imipenem. The G170N mutation, ascribed to a CC to AA base ...
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(University of Pretoria, 2010-03-01)Methicillin-resistant Staphylococcus aureus (MRSA) is a pandemic human pathogen accounting for most of health-care associated infections throughout the world. However, in recent years, a more virulent strain of MRSA has ...
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(University of Pretoria, 2015)Genetic typing of Klebsiella pneumoniae is used for epidemiological referencing. In the clinical setting it can be useful in outbreak investigations, understanding transmission and managing hospital infections. Multi-drug ...
Now showing items 1-20 of 29