• The role of Solute Carrier Family 7 Member 8 (SLC7A8) in adipogenesis in vitro and in a murine model of obesity 

  Pitere, Reabetswe (University of Pretoria, 2023)

  Obesity is a pandemic affecting both adults and children with an increasing annual prevalence. Adipogenesis, a process in which adipocyte precursors differentiate into mature adipocytes, is considered an important process ...
• The effect of cigarette smoke extract on the activity of clarithromycin with anti-pseudomonal agents on growth and biofilm formation of Pseudomonas aeruginosa 

  Sekalo, Lebogang (University of Pretoria, 2023)

  The present study was undertaken with the initial objective of investigating the effects of six primary anti-pseudomonal antibiotics, namely amikacin, cefepime, ciprofloxacin, meropenem, piperacillin and tazobactam, on the ...
• Influence of mesenchymal stromal cells and 2-methoxyestradiol in a murine model of spontaneous mammary carcinoma 

  Peta, Kimberly Thando (University of Pretoria, 2023)

  Breast cancer (BC) is the most prevalent cancer in females and the leading cause of cancer deaths. Treatment options include mastectomy, chemotherapy, and radiotherapy. While these treatments can improve 5-year survival ...
• Development of a high-throughput screening assay to evaluate compound libraries for the modulation of adipogenesis 

  Giles, Rachel (University of Pretoria, 2022)

  The aim of this project was to develop assays that will allow for high-throughput screening to monitor adipogenesis. Such an assay may be useful for the identification of potential drug targets during the process of ...
• Resistance and immune activation profiles in HIV-1 subtype C-infected subjects failing antiretroviral therapy 

  Malherbe, Glen Pierre (University of Pretoria, 2014)

  No abstract
• Isolation and characterization of the cytotoxicity, intracellular bioactivity and mechanism of antimycobacterial action of Euclea natalensis-derived naphthoquinones 

  Thaver, Veneesha (University of Pretoria, 2010)

  The major cause of HIV-related mortality in Sub-Saharan countries is pulmonary tuberculosis (TB), which is an escalating threat due to the emergence of multidrug resistant (MDR) and extremely multidrug resistant (XDR) TB. ...
• Optimising the efficacy of clofazimine against biofilm-encased Mycobacterium tuberculosis 

  Mashele, Sizeka Aubrey (University of Pretoria, 2020)

  Background: The chemotherapy of tuberculosis (TB) patients is administered for a six to nine- month period consisting of an intensive phase during the first two months with four primary anti- TB drugs, rifampicin (RMP), ...
• Effects of cigarette smoke condensate on clarithromycin-mediated inhibition of biofilm formation and related alterations in resistance gene expression by Streptococcus pneumonia 

  Matapa, Kgashane Given (University of Pretoria, 2019)

  Streptococcus pneumoniae (the pneumococcus) is a Gram-positive bacterium that frequently colonises the nasopharynx of healthy humans. In susceptible hosts, especially children under 5 years with underdeveloped immune systems ...
• Transcriptional analysis of the host response to HIV-1 infection in CD4+ T lymphocytes monocytes and macrophages 

  Wickham, Catherine Heather (University of Pretoria, 2019)

  The human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS), a condition characterized by depletion of CD4+ T cells and other immune system dysfunctions. Due to its widespread ...
• The role of Pref-1 in in vitro adipogenic differenctiation of mesenchymal stromal/stem cells 

  Da Silva, Carina Corte-Real (University of Pretoria, 2019)

  Obesity is characterized by an excessive amount of body fat which can negatively affect health as it is a risk factor for various non-communicable diseases such as cardiovascular disease and diabetes, amongst others. A ...
• Evaluating the effects of HIV-1 infection on haematopoietic stem cell colony formation 

  Herd, Candice Lee (University of Pretoria, 2019)

  The dissertation describes the production and titration of molecular clones of HIV-1B and HIV-1C primary isolates, as well as the assessment of haematopoietic stem and progenitor cell function by colony-forming unit assay ...
• Human leukocyte antigen (HLA) genetic diversity in South African populations 

  Tshabalala, Mqondisi (University of Pretoria, 2018)

  There is documented evidence of high genetic diversity amongst African populations, but there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA genes are highly polymorphic, and encode ...
• Optimisation of histocompatibility testing in living-donor renal transplantation 

  Kwofie, Luyanda Laura Illicia (University of Pretoria, 2018)

  The study addressed the development and evaluation of novel procedures for the rapid, reproducible and efficient measurement of T cell alloreactivity both pre- and post-transplantation, with the aim of optimizing donor/ ...
• Evaluation of circulating host-and pathogen-derived markers of infection and inflammation in the laboratory diagnosis of SEPSIS 

  Potjo, Moliehi (University of Pretoria, 2017)

  Patients with sepsis need to be distinguished from those with systemic inflammation due to non-infectious causes (SIRS) so that empiric antimicrobial therapy can be administered timeously to those with sepsis. The current ...
• The expansion and transduction of hematopoietic stem cells for gene therapy 

  Jackson, Carlo Stephan (University of Pretoria, 2017)

  Gene therapy is a field in medical research that is being investigated for the treatment of genetic, non-communicable and infectious diseases. The results obtained from clinical trials that make use of gene therapy show ...
• Effects of cigarette smoke and smoke condensate on neutrophil extracellular trap formation 

  Bokaba, Refilwe Philadelphia (University of Pretoria, 2016)

  Background: Neutrophil extracellular traps (NETs) constitute a network of chromatin fibres containing histone and antimicrobial peptides that are released by activated neutrophils. NETs protect the host against infection ...
• The effect of oxidative stress and hypoxic conditioning on mesenchymal stem cell differentiation 

  De Villiers, Danielle (University of Pretoria, 2015)

  Introduction South Africa is ranked the third most obese country after the United States of America and Great Britain. According to a study conducted by the South African Medical Research Council, 61% of the South African ...
• Rarefaction as a tool to determine variant diversity in monogenetic disorders 

  Van Rensburg, Jeanne (University of Pretoria, 2015)

  Genetic diversity is a well-described concept within many biological disciplines. However, mathematical models determining genetic diversity are often applied within ecological disciplines and are rarely explored within ...
• The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer 

  Wedi, Opope Oyaka (University of Pretoria, 2014)

  Background: Cancer is a crippling disease affecting 32.6 million people globally. It is currently ranked as the leading cause of death worldwide, and is associated with significant morbidity and mortality. Despite advances ...
• Isolation and characterization of human adipose derived mesenchymal stem cells and production of GFP-labeled primary cells for in vivo tracking following transplantation 

  Van Vollenstee, Fiona A. (University of Pretoria, 2015)

  Introduction It is well known that resident adipose stem/stromal cells (ASCs) are a heterogeneous population of multipotent cells characterized by (a) their ability to adhere to plastic; (b) immunophenotypic expression ...

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