Genetic testing of canine degenerative myelopathy in the South African Boxer dog population

Show simple item record Zeiler, Gareth Edward Van der Zwan, Henriette Oosthuizen, Marinda C. 2013-11-05T09:00:22Z 2013-11-05T09:00:22Z 2013-09-27
dc.description.abstract Canine degenerative myelopathy (DM) is a progressive disease process that is diagnosed late in life and mainly affects the pelvic limbs. Factors that make an ante-mortem definitive diagnosis of DM include: an insidious onset and clinical manifestation that mimics other disease processes of the pelvic limbs (hip dysplasia, cranial cruciate ligament rupture, etc.) or there may even be concurrent disease processes, old-age onset and lack of reliable diagnostic methods. Until recently, South African dog owners had to submit samples to laboratories overseas for genetic testing in order to confirm an affected dog (homozygous A/A) and to aid in the ante-mortem diagnosis of DM. Only affected dogs have been confirmed to manifest the clinical signs of DM. This study aimed to verify whether genetic testing by a local genetic laboratory was possible in order to detect a missense mutation of the superoxide dismutase gene (SOD1) that is implicated in causing the clinical signs of DM. The study also aimed to detect and map the inheritance of this disease process in a local Boxer dog population where the pedigree of the sampled population was known. Venous blood collected from Boxer dogs using a simple random sampling technique. The samples were genotyped for the SOD1:c.118G>A polymorphism. Carrier and affected Boxer dogs were detected. A pedigree that demonstrated the significance of inheriting a carrier or affected state in the population was mapped. The present study concludes that genotyping of the missense mutation in Boxer dogs is possible in South Africa. There are carrier and affected Boxer dogs in the local population, making DM a plausible diagnosis in aged dogs presenting with pelvic limb pathology. en
dc.description.librarian am2013 en
dc.description.librarian mn2013
dc.description.sponsorship The Wildlife Group (http:// of the South African Veterinary Association en
dc.description.uri en
dc.identifier.citation Zeiler, G.E., Van der Zwan, H. & & Oosthuizen, M.C., 2013, 'Genetic testing of canine degenerative myelopathy in the South African Boxer dog population', Journal of the South African Veterinary Association, 84(1), Art. #1005, 5 pages. 10.4102/jsava.v84i1.1005 en
dc.identifier.issn 0038-2809 (print)
dc.identifier.issn 2224-9435 (online)
dc.identifier.other 10.4102/jsava.v84i1.1005
dc.identifier.other 7004592997
dc.identifier.other N-8706-2014
dc.language.iso en en
dc.publisher OpenJournals Publishing en
dc.rights © 2013. The Authors. Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License. en
dc.subject Canine degenerative myelopathy (DM) en
dc.subject Pelvic limbs en
dc.subject Boxer dogs en
dc.subject Genetic testing en
dc.subject South Africa en
dc.subject Dog owners en_ZA
dc.subject.lcsh Dogs -- Diseases en
dc.title Genetic testing of canine degenerative myelopathy in the South African Boxer dog population en
dc.type Article en

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