Passive transfer and rate of decay of maternal antibody against African horse sickness virus in South African throughbred foals

Show simple item record Crafford, Jan Ernst Lourens, Carina W. Gardner, Ian A. MacLachlan, N.J. (James) Guthrie, Alan John 2013-10-28T07:22:48Z 2014-09-30T00:20:04Z 2013-09
dc.description.abstract REASONS FOR PERFORMING STUDY : African horse sickness is an insect transmitted, non-contagious disease of equids caused by African horse sickness virus (AHSV). Mortality can exceed 90% in fully susceptible horse populations. A live-attenuated (modified-live) cell culture-adapted (MLV) polyvalent AHSV vaccine is widely used to control AHS in endemic areas in southern Africa. Field studies detailing antibody responses of vaccinated horses are lacking. OBJECTIVES : To determine antibody titres to the 9 known serotypes of AHSV in a cohort of brood mares that were regularly vaccinated with the MLV AHSV vaccine, and to measure the passive transfer and rate of decay of maternal antibody to the individual virus serotypes in foals. METHODS : Serum was collected from 15 mares before foaling and from their foals after foaling and monthly thereafter for 6 months. Antibody titres to each of the 9 AHSV serotypes were determined by serum-virus neutralisation assay. RESULTS : There was marked variation in the antibody response of the mares to individual AHSV serotypes even after repeated vaccination, with consistently higher titre responses to some virus serotypes. Similarly, duration of maternally-derived antibodies in foals differed among serotypes. CONCLUSIONS : Data from this study confirm variation of the neutralising antibody response of individual mares to repeated vaccination with polyvalent AHSV vaccine. Virus strains of individual AHSV serotypes included in the vaccine may vary in their inherent immunogenicity. Passivelyacquired maternal antibodies to AHSV vary markedly among foals born to vaccinated mares, with further variation in the duration of passive immunity to individual AHSV serotypes. POTENTIAL RELEVANCE : These data are relevant to the effective utilization of live-attenuated AHSV vaccines in endemic regions, and potentially to the use of vaccines in response to future incursions of AHSV into previously free regions. Further studies involving a larger population will be required to determine the optimal time for vaccinating foals. en
dc.description.librarian hb2013 en
dc.description.librarian ab2013
dc.description.sponsorship Racing South Africa and the Equine Research Centre, University of Pretoria. en
dc.description.uri en
dc.identifier.citation Crafford, JE, Lourens, CW, Gardner, IA, Maclachlan, NJ & Guthrie, AJ 2013, 'Passive transfer and rate of decay of maternal antibody against African horse sickness virus in South African throughbred foals', Equine Veterinary Journal, vol. 45, no. 5, pp. 604-607. en
dc.identifier.issn 0425-1644 (print)
dc.identifier.other 10.1111/evj.12015
dc.identifier.other 7006535470
dc.identifier.other J-6375-2013
dc.identifier.other 0000-0001-7729-9918
dc.language.iso en en
dc.publisher Wiley-Blackwell en
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2012 EVJ Ltd. The definite version is available at en
dc.subject Horses en
dc.subject Passive transfer en
dc.subject Maternal antibody en
dc.subject Neutralising antibody en
dc.subject Antibody half-life en
dc.subject AHSV en
dc.subject.lcsh African horse sickness virus -- Vaccination en
dc.subject.lcsh Horses -- Diseases en
dc.subject.lcsh Foals en
dc.title Passive transfer and rate of decay of maternal antibody against African horse sickness virus in South African throughbred foals en
dc.type Postprint Article en

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