Assessing the impact of feline immunodeficiency virus and bovine tuberculosis co-infection in African lions

Show simple item record Maas, Miriam Keet, D.F. Rutten, Victor P.M.G. Heesterbeek, J.A.P. Nielen, Mirjam 2013-10-21T07:28:01Z 2013-10-21T07:28:01Z 2012-08
dc.description.abstract Bovine tuberculosis (BTB), caused by Mycobacterium bovis, is a disease that was introduced relatively recently into the Kruger National Park (KNP) lion population. Feline immunodeficiency virus (FIVple) is thought to have been endemic in lions for a much longer time. In humans, co-infection between Mycobacterium tuberculosis and human immunodeficiency virus increases disease burden. If BTB were to reach high levels of prevalence in lions, and if similar worsening effects would exist between FIVple and BTB as for their human equivalents, this could pose a lion conservation problem. We collected data on lions in KNP from 1993 to 2008 for spatio-temporal analysis of both FIVple and BTB, and to assess whether a similar relationship between the two diseases exists in lions.We found thatBTBprevalence in the southwas higher than in the north (72 versus 19%over the total study period) and increased over time in the northern part of the KNP (0–41%). No significant spatio-temporal differences were seen for FIVple in the study period, in agreement with the presumed endemic state of the infection. Both infections affected haematology and blood chemistry values, FIVple in a more pronounced way than BTB. The effect of co-infection on these values, however, was always less than additive. Though a large proportion (31%) of the lions was co-infected with FIVple and M. bovis, there was no evidence for a synergistic relation as in their human counterparts. Whether this results from different immunopathogeneses remains to be determined. en
dc.description.librarian hb2013 en
dc.description.librarian ab2013
dc.description.sponsorship The South African Veterinary Foundation and the Directorate of Veterinary Services, National Department of Agriculture,Forestry and Fisheries, South Africa. D.F. Keet was the recipient of a doctoral bursary awarded by the University of Pretoria. The work of M. Maas was supported by the Netherlands Organisation for Scientific Research (NWO/ZonMw grant 918.56.620). en
dc.description.uri en
dc.identifier.citation Maas, M, Keet, DF, Rutten, VPMG, Heesterbeek, JAP & Nielen, M 2012, 'Assessing the impact of feline immunodeficiency virus and bovine tuberculosis co-infection in African lions', Proceedings of the Royal Society B: Biological Sciences, vol. 279, no. 1745, pp. 4206-4214. en
dc.identifier.issn 0962-8452 (print)
dc.identifier.issn 1471-2954 (online)
dc.identifier.other 10.1098/rspb.2012.1503
dc.language.iso en en
dc.publisher The Royal Society en
dc.relation.requires Adobe Acrobat Reader en
dc.rights © The Royal Society 2012 en
dc.subject Bovine tuberculosis en
dc.subject Mycobacterium bovis en
dc.subject Panthera en
dc.subject Co-infection en
dc.subject Prevalence en
dc.subject.lcsh Feline immunodeficiency virus en
dc.subject.lcsh Tuberculosis in cattle en
dc.subject.lcsh Lion en
dc.title Assessing the impact of feline immunodeficiency virus and bovine tuberculosis co-infection in African lions en
dc.type Postprint Article en

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