Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa
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| dc.contributor.author | Kock, Marleen M.
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| dc.contributor.author | Bellomo, Alessandro N.
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| dc.contributor.author | Storm, Nadia
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| dc.contributor.author | Ehlers, Marthie Magdaleen
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| dc.date.accessioned | 2013-10-11T07:36:32Z | |
| dc.date.available | 2013-10-11T07:36:32Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Acinetobacter baumannii is an important cause of hospital-acquired infections. The occurrence of carbapenem resistance that is caused by the carbapenem-hydrolysing class D β-lactamases and the metallo-β-lactamases (MBLs) limits the range of therapeutic alternatives in treating A. baumannii infections. In this study, two multiplex polymerase chain reactions were performed to screen for both carbapenem-hydrolysing class D β-lactamases and MBL genes in 97 clinical isolates of A. baumannii. Oxacillinase (OXA)-51 had a prevalence of 83% (81/97), and OXA-23 had a prevalence of 59% (57/97). One isolate was positive for an MBL [Verona integron-encoded metallo β-lactamases (VIM)]. Therefore, continuous surveillance and monitoring of A. baumannii is crucial because of the high prevalence of antibiotic resistance genes. | en_US |
| dc.description.librarian | am2013 | en_US |
| dc.description.librarian | ay2013 | |
| dc.description.uri | http://www.sajei.co.za/index.php/SAJEI | en_US |
| dc.identifier.citation | Kock, MM, Bellomo, AN, Storm, N & Ehlers, MM 2013, 'Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa', Southern African Journal of Epidemiology & Infection, vol. 28, no. 1, pp. 28-32. | en_US |
| dc.identifier.issn | 1015-8782 | |
| dc.identifier.uri | http://hdl.handle.net/2263/32027 | |
| dc.language.iso | en | en_US |
| dc.publisher | Federation of Infectious Diseases Societies of South Africa | en_US |
| dc.rights | © SAJEI | en_US |
| dc.subject | Acinetobacter baumannii | en_US |
| dc.subject | Carbapenem-hydrolysing class D-β-lactamases | en_US |
| dc.subject | Metallo-β-lactamases | en_US |
| dc.subject.lcsh | Drug resistance in microorganisms -- South Africa | en |
| dc.subject.lcsh | Acinetobacter infections -- South Africa | en |
| dc.title | Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa | en_US |
| dc.type | Article | en_US |
