Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa
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Date
Authors
Kock, Marleen M.
Bellomo, Alessandro N.
Storm, Nadia
Ehlers, Marthie Magdaleen
Journal Title
Journal ISSN
Volume Title
Publisher
Federation of Infectious Diseases Societies of South Africa
Abstract
Acinetobacter baumannii is an important cause of hospital-acquired infections. The occurrence of carbapenem resistance that is
caused by the carbapenem-hydrolysing class D β-lactamases and the metallo-β-lactamases (MBLs) limits the range of therapeutic
alternatives in treating A. baumannii infections. In this study, two multiplex polymerase chain reactions were performed to screen for both carbapenem-hydrolysing class D β-lactamases and MBL genes in 97 clinical isolates of A. baumannii. Oxacillinase (OXA)-51 had a prevalence of 83% (81/97), and OXA-23 had a prevalence of 59% (57/97). One isolate was positive for an MBL
[Verona integron-encoded metallo β-lactamases (VIM)]. Therefore, continuous surveillance and monitoring of A. baumannii is
crucial because of the high prevalence of antibiotic resistance genes.
Description
Keywords
Acinetobacter baumannii, Carbapenem-hydrolysing class D-β-lactamases, Metallo-β-lactamases
Sustainable Development Goals
Citation
Kock, MM, Bellomo, AN, Storm, N & Ehlers, MM 2013, 'Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa', Southern African Journal of Epidemiology & Infection, vol. 28, no. 1, pp. 28-32.