Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa

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Authors

Kock, Marleen M.
Bellomo, Alessandro N.
Storm, Nadia
Ehlers, Marthie Magdaleen

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Federation of Infectious Diseases Societies of South Africa

Abstract

Acinetobacter baumannii is an important cause of hospital-acquired infections. The occurrence of carbapenem resistance that is caused by the carbapenem-hydrolysing class D β-lactamases and the metallo-β-lactamases (MBLs) limits the range of therapeutic alternatives in treating A. baumannii infections. In this study, two multiplex polymerase chain reactions were performed to screen for both carbapenem-hydrolysing class D β-lactamases and MBL genes in 97 clinical isolates of A. baumannii. Oxacillinase (OXA)-51 had a prevalence of 83% (81/97), and OXA-23 had a prevalence of 59% (57/97). One isolate was positive for an MBL [Verona integron-encoded metallo β-lactamases (VIM)]. Therefore, continuous surveillance and monitoring of A. baumannii is crucial because of the high prevalence of antibiotic resistance genes.

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Keywords

Acinetobacter baumannii, Carbapenem-hydrolysing class D-β-lactamases, Metallo-β-lactamases

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Citation

Kock, MM, Bellomo, AN, Storm, N & Ehlers, MM 2013, 'Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa', Southern African Journal of Epidemiology & Infection, vol. 28, no. 1, pp. 28-32.