Designing programs for eliminating canine rabies from Islands : Bali, Indonesia as a case study

Show simple item record Townsend, Sunny E. Sumantra, I. Putu Pudjiatmoko Bagus, Gusti Ngurah Brum, Eric Cleaveland, Sarah Crafter, Sally Dewi, Ayu P.M. Dharma, Dewa Made Ngurah Dushoff, Jonathan Girardi, Janice Gunata, I. Ketut Hiby, Elly F. Kalalo, Corlevin Knobel, Darryn Leslie Mardiana, I. Wayan Putra, Anak Agung Gde Schoonman, Luuk Scott-Orr, Helen Shand, Mike Sukanadi, I. Wayan Suseno, Pebi Purwo Haydon, Daniel Thomas Hampson, Katie 2013-10-10T07:14:01Z 2013-10-10T07:14:01Z 2013-08-22
dc.description.abstract BACKGROUND: Canine rabies is one of the most important and feared zoonotic diseases in the world. In some regions rabies elimination is being successfully coordinated, whereas in others rabies is endemic and continues to spread to uninfected areas. As epidemics emerge, both accepted and contentious control methods are used, as questions remain over the most effective strategy to eliminate rabies. The Indonesian island of Bali was rabies-free until 2008 when an epidemic in domestic dogs began, resulting in the deaths of over 100 people. Here we analyze data from the epidemic and compare the effectiveness of control methods at eliminating rabies. METHODOLOGY/PRINCIPAL FINDING: Using data from Bali, we estimated the basic reproductive number, R0, of rabies in dogs, to be ,1?2, almost identical to that obtained in ten–fold less dense dog populations and suggesting rabies will not be effectively controlled by reducing dog density. We then developed a model to compare options for mass dog vaccination. Comprehensive high coverage was the single most important factor for achieving elimination, with omission of even small areas (,0.5% of the dog population) jeopardizing success. Parameterizing the model with data from the 2010 and 2011 vaccination campaigns, we show that a comprehensive high coverage campaign in 2012 would likely result in elimination, saving ,550 human lives and ,$15 million in prophylaxis costs over the next ten years. CONCLUSIONS/SIGNIFICANCE: The elimination of rabies from Bali will not be achieved through achievable reductions in dog density. To ensure elimination, concerted high coverage, repeated, mass dog vaccination campaigns are necessary and the cooperation of all regions of the island is critical. Momentum is building towards development of a strategy for the global elimination of canine rabies, and this study offers valuable new insights about the dynamics and control of this disease, with immediate practical relevance. en
dc.description.librarian am2013 en
dc.description.librarian ab2013
dc.description.sponsorship This study was funded by the UK Medical Research Council (grant G0901135), the Wellcome Trust (grant 095787/Z/11/Z), the RAPIDD program of the Science and Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health. en
dc.description.uri en
dc.identifier.citation Townsend SE, Sumantra IP, Pudjiatmoko, Bagus GN, Brum E, et al. (2013) Designing Programs for Eliminating Canine Rabies from Islands: Bali, Indonesia as a Case Study. PLoS Negl Trop Dis 7(8): e2372. DOI: 10.1371/journal.pntd.0002372 en
dc.identifier.issn 1932-6203
dc.identifier.other 10.1371/journal.pntd.0002372
dc.identifier.other 6602518021
dc.identifier.other O-7057-2014
dc.identifier.other 0000-0002-0425-3799
dc.language.iso en en
dc.publisher Public Library of Science en
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2013 Townsend et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License en
dc.subject Canine rabies en
dc.subject Indonesian island of Bali en
dc.subject.lcsh Dogs -- Virus diseases en
dc.subject.lcsh Rabies in dogs en
dc.subject.lcsh Veterinary virology en
dc.subject.lcsh Rabies in animals en
dc.subject.lcsh Dogs -- Diseases en
dc.title Designing programs for eliminating canine rabies from Islands : Bali, Indonesia as a case study en
dc.type Article en

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