Browsing Psychiatry by Author "Karayiorgou, Maria"

Browsing Psychiatry by Author "Karayiorgou, Maria"

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  • Aberrant function of the C-terminal tail of HIST1H1E accelerates cellular senescence and causes premature aging 
    Flex, Elisabetta; Martinelli, Simone; Van Dijck, Anke; Ciolfi, Andrea; Cecchetti, Serena; Coluzzi, Elisa; Pannone, Luca; Andreoli, Cristina; Radio, Francesca Clementina; Pizzi, Simone; Carpentieri, Giovanna; Bruselles, Allessandro; Catanzaro, Giuseppina; Pedace, Lucia; Miele, Evelina; Carcarino, Elena; Ge, Xiaoyan; Chijiwa, Chieko; Lewis, M.E. Suzanne; Meuwissen, Marije; Kenis, Sandra; Van der Aa, Nathalie; Larson, Austin; Brown, Kathleen; Wasserstein, Melissa P.; Skotko, Brian G.; Begtrup, Amber; Person, Richard; Karayiorgou, Maria; Roos, J.L. (Johannes Louw); Van Gassen, Koen L.; Koopmans, Marije; Bijlsma, Emilia K.; Santen, Gijs W.E.; Barge-Schaapveld, Daniela Q.C.M.; Ruivenkamp, Claudia A.L.; Hoffer, Mariette J.V.; Lalani, Seema R.; Streff, Haley; Craigen, William J.; Graham, Brett H.; Van den Elzen, Annette P.M.; Kamphuis, Daan J.; Ounap, Katrin; Reinson, Karit; Pajusalu, Sander; Wojcik, Monica H.; Viberti, Clara; Di Gaetano, Cornelia; Bertini, Enrico; Petrucci, Simona; De Luca, Alessandro; Rota, Rossella; Ferretti, Elisabetta; Matullo, Giuseppe; Dallapiccola, Bruno; Sgura, Antonella; Walkiewicz, Magdalena; Kooy, R. Frank; Tartaglia, Marco (Elsevier, 2019-09)
    Histones mediate dynamic packaging of nuclear DNA in chromatin, a process that is precisely controlled to guarantee efficient compaction of the genome and proper chromosomal segregation during cell division and to accomplish ...
  • Cobalt(III) protoporphyrin activates the DGCR8 protein and can compensate microRNA processing deficiency 
    Barr, Ian; Weitz, Sara H.; Atkin, Talia; Hsu, PeiKen; Karayiorgou, Maria; Gogos, Joseph A.; Weiss, Shimon; Guo, Feng (Elsevier, 2015-06-18)
    Processing of microRNA primary transcripts (pri-miRNAs) is highly regulated and defects in the processing machinery play a key role in many human diseases. In 22q11.2 deletion syndrome (22q11.2DS), heterozygous deletion ...
  • Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice 
    Levy, R.J.; Kvajo, M.; Li, Y.; Tsvetkov, E.; Dong, W.; Yoshikawa, Y.; Kataoka, T.; Bolshakov, V.Y.; Karayiorgou, Maria; Gogos, J.A. (Nature Publishing Group, 2015-06-09)
    In human genetic studies of schizophrenia, we uncovered copy-number variants in RAPGEF6 and RAPGEF2 genes. To discern the effects of RAPGEF6 deletion in humans, we investigated the behavior and neural functions of a mouse ...
  • Family history identifies sporadic schizoaffective disorder as a subtype for genetic studies 
    Van der Merwe, Nicolaas J.; Karayiorgou, Maria; Ehlers, Rene; Roos, J.L. (Johannes Louw) (AOSIS Open Journals, 2020-04)
    BACKGROUND : Schizophrenia is a heterogeneous disorder with strong genetic vulnerability. Family history of schizophrenia has been considered in genetic studies under several models. De novo genetic events seem to play a ...
  • Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia 
    Rodriguez-Murillo, Laura; Xu, Bin; Roos, J.L. (Johannes Louw); Abecasis, G.R.; Gogos, Joseph A.; Karayiorgou, Maria (Nature Publishing Group, 2014-03)
    We previously reported linkage of schizophrenia and schizoaffective disorder to 13q32–34 in the European descent Afrikaner population from South Africa. The nature of genetic variation underlying linkage peaks in psychiatric ...
  • Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene 
    Takata, Atsushi; Xu, Bin; Ionita-Laza, Iuliana; Roos, J.L. (Johannes Louw); Gogos, Joseph A.; Karayiorgou, Maria (Elsevier, 2014-05)
    Loss-of-function (LOF) (i.e., nonsense, splice site, and frameshift) variants that lead to disruption of gene function are likely to contribute to the etiology of neuropsychiatric disorders. Here, we perform a systematic ...
  • Meta-analysis of 32 genome-wide linkage studies of schizophrenia 
    Ng, M.Y.M.; Levinson, D.F.; Faraone, S.V.; Suarez, B.K.; DeLisi, L.E.; Arinami, T.; Riley, B.; Paunio, T.; Pulver, A.E.; Irmansya; Holmans, P.A.; Escamilla, M.; Wildenauer, D.B.; Williams, Neal M.; Laurent, Claude; Mowry, B.J.; Brzustowicz, L.M.; Maziade, M.; Sklar, P.; Garver, D.L.; Abecasis, G.R.; Lerer, B.; Fallin, M.D.; Gurling, H.M.D.; Gejman, P.V.; Lindholm, E.; Moises, H.W.; Byerley, W.; Wijsman, E.M.; Foraboso, P.; Tsuang, M.T.; Hwu, H-G.; Okazaki, Y.; Kendler, K.S.; Wormley, B.; Fanous, A.; Walsh, D.; O'Neill, F.A.; Peltonen, L.; Nestadt, G.; Lasseter, V.K.; Liang, K.Y.; Papadimitriou, G.M.; Dikeos, D.G.; Schwab, S.G.; Owen, M.J.; O'Donovan, M.C.; Norton, N.; Hare, E.; Raventos, H.; Nicolini, H.; Albus, M.; Maier, W.; Nimgaonkar, V.L.; Terenius, L.; Mallet, J.; Jay, M.; Godard, S.; Nertney, D.; Alexander, M.; Crowe, R.R.; Silverman, J.M.; Basset, A.S.; Roy, M-A.; Merette, C.; Pato, C.N.; Pato, M.T.; Roos, J.L. (Johannes Louw); Kohn, Y.; Amann-Zalcenstein, D.; Kalsi, G.; McQuillin, A.; Curtis, D.; Brynjolfson, J.; Sigmundsson, T.; Petursson, H.; Sanders, A.R.; Duan, J.; Jazin, E.; Myles-Worsley, M.; Karayiorgou, Maria; Lewis, C.M. (Nature Publishing Group, 2009-08)
    A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia SCZ) or related disorders. The primary ...
  • Phenotypic features of patients with schizophrenia carrying de novo gene mutations : a pilot study 
    Malherbe, P.J.; Roos, J.L. Jr.; Ehlers, Rene; Karayiorgou, Maria; Roos, J.L. (Johannes Louw) (Elsevier, 2015-01)
    Genome-wide scans have revealed a significant role for de novo copy number variants (CNVs) and Single Nucleotide variants (SNVs) in the genetic architecture of schizophrenia. The present study attempts to parse schizophrenia ...
  • Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism 
    Ionita-Laza, Iuliana; Xu, Bin; Makarov, Vlad; Buxbaum, Joseph D.; Roos, J.L. (Johannes Louw); Gogos, Joseph A.; Karayiorgou, Maria (National Academy of Sciences, 2014-01)
    We used a family-based cluster detection approach designed to localize significant rare disease–risk variants clusters within a region of interest to systematically search for schizophrenia (SCZ) susceptibility genes ...