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Browsing Research Articles (Pharmacology) by Subject "Endogenous retrovirus"

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A new therapeutic approach for type 1 diabetes : rationale for GNbAC1, an anti‐HERV‐W‐Env monoclonal antibody

Curtin, Francois; Bernard, Corinne; Levet, Sandrine; Perron, Hervé; Porchet, Hervé; Medina, Julie; Malpass, Sam; Lloyd, David; Simpson, Richard (Wiley, 2018-09)

We describe a newly identified therapeutic target for type 1 diabetes (T1D): an envelope protein of endogenous retroviral origin, human endogenous retrovirus W envelope (HERV‐W‐Env). HERV‐W‐Env was found to be detected in ...
A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients

Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; Rasenack, Maria; Matthey, Alain; Du Pasquier, Renaud; Schluep, Myriam; Desmeules, Jules; Lang, Alois B.; Perron, Hervé; Faucard, Raphael; Porchet, Hervé; Hartung, Hans-Peter; Kappos, Ludwig; Lalive, Patrice H. (Sage, 2015-06)

BACKGROUND : GNbAC1 is an immunoglobulin (IgG4) humanised monoclonal antibody against multiple sclerosis-associated retrovirus (MSRV)-Env, a protein of endogenous retroviral origin, expressed in multiple sclerosis (MS) ...
A randomised placebo-controlled study to investigate GNbAC1 an anti-HERV-W-Env monoclonal antibody in patients with recent onset of type 1 diabetes : rationale and design

Curtin, F.; Bernard, C.; Porchet, Hervé; Levet, S.; Medina, J.; Perron, H.; Oates, S.; Lloyd, D.; Simpson, R. (Wiley, 2018)

AIMS : Human endogenous retroviruses (HERVs) elements, remnants of ancestral viral genomic insertions, are emerging targets in several autoimmune diseases. In type 1 diabetes (T1D) patients, the envelope protein of HERV-W ...

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Browsing Research Articles (Pharmacology) by Subject "Endogenous retrovirus"

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