Browsing Research Articles (Pharmacology) by Title

Browsing Research Articles (Pharmacology) by Title

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  • Beneficial effects of folic acid on the kidneys and testes of adult albino rats after exposure to methomyl 
    Sakr, Samar; Hassanien, Hanan; Bester, Megan Jean; Arbi, Sandra; Sobhy, Azza; El Negris, Heba; Steenkamp, Vanessa (Royal Society of Chemistry, 2018-03)
    The aim of this study was to evaluate the protective effect of folate against methomyl-induced toxicity on the kidneys and testes of male rats. Adult male albino rats were divided into four groups; Group I served as the ...
  • Binding pose analysis of hydroxyethylamine based β-secretase inhibitors and application thereof to the design and synthesis of novel indeno[1,2-b]indole based inhibitors 
    Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)
    β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
  • Bioavailability of resveratrol : possibilities for enhancement 
    De Vries, Konrad; Strydom, Morne A.; Steenkamp, Vanessa (Elsevier, 2018-03)
    Resveratrol is a naturally occurring polyphenol that has been shown to elicit a variety of beneficial effects in vitro. Translating these gains to in vivo and clinical settings has proven to be a major challenge, because ...
  • Bipolar disorder : an update 
    Outhoff, Kim (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2017)
    Bipolar disorder, characterised by alternating discrete episodes of (hypo)mania and depression, provides unique diagnostic and treatment challenges. Updated diagnostic (DSM-5) and current pharmacological treatment ...
  • A brief updated review of advances to enhance resveratrol’s bioavailability 
    De Vries, Konrad; Strydom, Morne A.; Steenkamp, Vanessa (MDPI, 2021-07-20)
    Resveratrol (RES) has a low bioavailability. This limitation was addressed in an earlier review and several recommendations were offered. A literature search was conducted in order to determine the extent of the research ...
  • Brown coal derived humate inhibits contact hypersensitivity : an efficacy, toxicity and teratogenicity study in rats 
    Jansen van Rensburg, Connie E.; Snyman, Jacques Rene; Mokoele, T.L.; Cromarty, Allan Duncan (Springer, 2007-10)
    OBJECTIVES:The effects of two humate products were compared to that of prednisolone on a contact hypersensitivity rat model. METHODS: Rats, sensitized with dinitrofluorobenzene (DNFB), were placed on a daily oral treatment ...
  • Bulb extracts of Boophone disticha induce hepatotoxicity by perturbing growth, without significantly impacting cellular viability 
    Cordier, Werner; Steenkamp, Vanessa (Elsevier, 2018-01)
    INTRODUCTION : Traditional remedies remain a prominent form of therapy in developing countries, such as South Africa. Boophone disticha, or the poison bulb, is used for the treatments of wounds. There is generally a lack ...
  • Burning issues in acute heart failure management 
    Ker, James A.; Outhoff, Kim (Medpharm Publications, 2019-12)
    In general, heart failure is the end-stage manifestation of cardiovascular disease and is an important and increasing cause of morbidity worldwide. Acute heart failure, whether of new onset or an exacerbation of chronic ...
  • Burning issues in blood pressure control 
    Ker, James A.; Outhoff, Kim (OASIS, 2019-03)
    Globally more than 1 billion people have hypertension and it is predicted that because of ageing populations and increasing sedentary lifestyles, this figure will rise to about 1.5 billion by 2025. Elevated blood pressure ...
  • Burning issues in the prevention of heart failure 
    Ker, James A.; Outhoff, Kim (AOSIS Open Journals, 2019-07)
    Chronic heart failure is common, debilitating, and often the culmination of pervasive cardiovascular insults that systematically undermine the heart’s circulatory capacity and invoke counterproductive neuro-hormonal ...
  • Burning issues in the prevention of heart failure 
    Ker, James A.; Outhoff, Kim (MedPharm Publications, 2020-08)
    Chronic heart failure is common, debilitating, and often the culmination of pervasive cardiovascular insults that systematically undermine the heart’s circulatory capacity and invoke counterproductive neuro-hormonal ...
  • Cannabidiol-mediated green synthesis, characterization, and cytotoxicity of metal nanoparticles in human keratinocyte cells 
    Josiah, Andrea Jess; Pillai, Sreejarani Kesavan; Cordier, Werner; Nell, Margo Judith; Twilley, Danielle; Lall, Namrita; Ray, Suprakas Sinha (American Chemical Society, 2021-10-21)
    This study investigated a unique one-pot microwave- assisted green synthesis method of gold (Au) and silver (Ag) nanoparticles (NPs) using cannabidiol (CBD) as a capping and reducing agent. Furthermore, Au and Ag NPs ...
  • Carbohydrate-derived fulvic acid (CHD-FA) inhibits carrageenan-induced inflammation and enhances wound healing : efficacy and toxicity study in rats 
    Sabi, Riaz Ahmed; Vrey, Pieter Jakobus; Jansen van Rensburg, Constance Elizabeth (Wiley-Blackwell, 2012-01)
    The objectives of this study were to evaluate the safety and anti-inflammatory and wound healing characteristics of carbohydrate derived fulvic acid (CHD-FA) in rats. A daily oral dosage of CHD-FA at 100mg/kg and higher ...
  • Case study 
    Muntingh, George L. (MedPharm Publications, 2015)
    During a dissection practical in the Anatomy Department of the University of Pretoria, students found an unknown tablet in the rectum of a male cadaver (Fig 1). The deceased was approximately 68 years of age and the ...
  • Characterization and reproducibility of HepG2 hanging drop spheroids toxicology in vitro 
    Hurrell, Tracey; Ellero, Andrea Antonio; Masso, Zelie Flavienne; Cromarty, Allan Duncan (Elsevier, 2018-08)
    Hepatotoxicity remains a major challenge in drug development despite preclinical toxicity screening using hepatocytes of human origin. To overcome some limitations of reproducing the hepatic phenotype, more structurally ...
  • Clinical efficacy of potassium humate in the treatment of allergic rhinitis : double-blind placebo-controlled trial 
    Gandy, Justin John; Meeding, Johanna Petronella; Snyman, Jacques Rene; Jansen van Rensburg, Constance Elizabeth (Wiley-Blackwell, 2010-09)
    The anti-inflammatory properties of products that contain high levels of humic acid, such as peat, sapropeles, and mumie, are well described. The aim of this study was to establish the clinical efficacy of brown coal-derived ...
  • Clinical evidence in the management of swimmer’s ear 
    Marais, Andre (MedPharm Publications, 2015)
    “Swimmer’s ear” or acute otitis externa is a common condition involving the exterior part of the ear, including the ear canal and the pinna. Inflammation and pain are the main features, with bacterial infection mainly due ...
  • Clinical pharmacology becomes a specialty in South Africa 
    Walubo, A.; Barnes, K.; Kwizera, E.; Greeff, Oppel Bernhardt Wilhelm; Rosenkranz, B.; Maartens, G. (Health and Medical Publishing Group, 2013-03)
    South Africa recently became the first African country where clinical pharmacology has been approved as a specialty. This article outlines the need for clinical pharmacologists, their role in advancing public health, ...
  • Cognitive enhancement : a brief overview 
    Outhoff, Kim (MedPharm Publications, 2016)
    Cognitive enhancement involves the non-medical use of illicit and/or prescription drugs, such as agents prescribed for attention deficit/hyperactive disorder (ADHD) and narcolepsy, usually in order to stay awake and to ...
  • Common cutaneous dermatophyte infections of the skin and nails 
    Marais, Andre; Osuch, Elzbieta (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2017)
    Superficial fungal infections occur in approximately 20% of the population. Dermatophyte infections are mainly caused by organisms from the Trichophyton, Epidermophyton, and Microsporum genera, and should not be confused ...