Browsing Pharmacology by UP Author "Nell, Margo Judith"

Now showing items 1-11 of 11

The ability of three African herbal remedies to offer protection against an in vitro model of Parkinson’s disease

Lepule, Keagile Hilda; Cordier, Werner; Steenkamp, Paul; Nell, Margo Judith; Steenkamp, Vanessa (Elsevier, 2019-11)

Parkinson’s disease, characterised by loss of dopaminergic neurons in the substantia nigra of the brain, is attributed to oxidative stress and mitochondrial dysfunction. As no cure is available, and dopamine-replacement ...
The anti-tumour properties and biodistribution (as determined by the radiolabeled equivalent) of Au-compounds intended as potential chemotherapeutics

Nell, Margo Judith; Wagener, Judith Marie; Zeevaart, Jan Rijn; Kilian, Elmare; Mamo, Messai Adenew; Layh, Marcus; Coyanis, M.; Jansen van Rensburg, Connie E. (Elsevier, 2009-07)

The anti-tumour activity of the Au (I) phosphine complex [Au(dppe2]Cl was first discovered in the mid 1980s although promising results were obtained it did not pass clinical studies because of its toxicity to organs such ...
Binding pose analysis of hydroxyethylamine based β-secretase inhibitors and application thereof to the design and synthesis of novel indeno[1,2-b]indole based inhibitors

Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)

β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
Cannabidiol-mediated green synthesis, characterization, and cytotoxicity of metal nanoparticles in human keratinocyte cells

Josiah, Andrea Jess; Pillai, Sreejarani Kesavan; Cordier, Werner; Nell, Margo Judith; Twilley, Danielle; Lall, Namrita; Ray, Suprakas Sinha (American Chemical Society, 2021-10-21)

This study investigated a unique one-pot microwave- assisted green synthesis method of gold (Au) and silver (Ag) nanoparticles (NPs) using cannabidiol (CBD) as a capping and reducing agent. Furthermore, Au and Ag NPs ...
Hybrid compounds containing carvacrol scaffold : in vitro antibacterial and cytotoxicity evaluation

Mbese, Zintle; Nell, Margo Judith; Fonkui, Youmbi Thierry; Ndinteh, Derek Tantoh; Steenkamp, Vanessa; Aderibigbe, Blessing Atim (Bentham Science Publishers, 2022-03)

Please read abstract in the article.
A multi-centre, phase IV study to evaluate the steady-state plasma concentration and serum bactericidal activity of a generic teicoplanin preparation

Greeff, Oppel Bernhardt Wilhelm; Van Tonder, Jacob John; Cromarty, Allan Duncan; Lowman, Warren; Becker, Piet J.; Nell, Margo Judith (MedPharm Publications, 2015)

INTRODUCTION : Teicoplanin is an effective treatment option against methicillin-resistant, Gram-positive bacteria, like Staphylococcus aureus. It is a glycopeptide antibiotic, produced through microbial fermentation, a ...
Novel N-heterocyclic ylideneamine gold(I) complexes : synthesis, characterisation and screening for antitumour and antimalarial activity

Coetzee, Jacorien; Cronje, Stephanie; Dobrzanska, Liliana; Raubenheimer, Helgard G.; Joone, Gisela Käthe; Nell, Margo Judith; Hoppe, Heinrich C. (Royal Society of Chemistry, 2011-01)

Ylideneamine functionalised heterocyclic ligands, 1,3-dimethyl-1,3-dihydro-benzimidazol-2-ylideneamine (I), 3-methyl-3H-benzothiazol-2-ylideneamine (II) or 3,4-dimethyl-3H-thiazol-2-ylideneamine (III), were employed in the ...
One-step synthesis of metal oxide nanoparticles using cannabidiol: characterisation and cytotoxicity assessment in human keratinocyte cells

Josiah, Andrea Jess; Pillai, Sreejarani K.; Cordier, Werner; Nell, Margo Judith; Lall, Namrita; Twilley, Danielle; Ray, Suprakas Sinha (Wiley, 2024-02)

Please read abstract in the article.
Phosphinogold(I) dithiocarbamate complexes : effect of the nature of phosphine ligand on anticancer properties

Keter, Frankline K.; Guzei, Ilia A.; Nell, Margo Judith; Van Zyl, Werner E.; Darkwa, James (American Chemical Society, 2014-02)

The reactions of potassium salts of the dithiocarbamates L {where L = pyrazolyldithiocarbamate (L1), 3,5-dimethylpyrazolyldithiocarbamate (L2), or indazolyldithiocarbamate (L3)} with the gold precursors [AuCl(PPh3)], ...
A randomised clinical trail comparing the analgesic and anxiolytic efficacy and tolerability of Stilpane® and Tramacet® after third molar extraction

Outhoff, Kim; Dippenaar, Johannes Marthinus (Tinus); Nell, Margo Judith; Royds, M.; Greeth, O.B.W. (MedPharm Publications, 2015)

BACKGROUND : successful treatment of moderate to severe acute pain often necessitates several analgesics that target different sites of the nociceptive pathway. Fixed-dose combination analgesics facilitate a reduction in ...
Underlying mechanisms of cytotoxicity in HepG2 hepatocarcinoma cells exposed to arsenic, cadmium and mercury individually and in combination

Cordier, Werner; Yousaf, Muhammad; Nell, Margo Judith; Steenkamp, Vanessa (Elsevier, 2021-04)

BACKGROUND : Toxicity data regarding combinational exposure of humans to arsenic, cadmium and mercury is scarce. Although hepatotoxicity has been reported, limited information is available on their mechanistic underpinnings. ...

Now showing items 1-11 of 11

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Browsing Pharmacology by UP Author "Nell, Margo Judith"

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