Browsing Research Articles (Internal Medicine) by Title

Browsing Research Articles (Internal Medicine) by Title

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  • Third-line antiretroviral therapy program in the South African public sector : cohort description and virological outcomes 
    Moorhouse, Michelle; Maartens, Gary; Venter, Willem Daniel Francois; Moosa, Mahomed-Yunus; Steegen, Kim; Jamaloodien, Khadija; Fox, Matthew P.; Conradie, Francesca (Lippincott Williams and Wilkins, 2019-01-01)
    BACKGROUND : The World Health Organization recommends that antiretroviral therapy (ART) programs in resource-limited settings develop third-line ART policies. South Africa developed a national third-line ART program for ...
  • Thrombotic complications 
    Ker, James A. (New Media Publishing, 2015-09)
    There have been significant advances in the treatment of heart failure (HF) with a reduction in mortality. Despite this improvement in mortality, HF still has a bad prognosis and research is ongoing to find ways to improve ...
  • A thyroid-related endocrine emergency in pregnancy 
    Delport, Eluned F. (Health and Medical Publishing Group, 2009)
    A 28-year-old woman presented with a thyroid storm while pregnant. Thyroid storm in pregnancy is a rare, life threatening endocrinological emergency. The diagnosis and management can be challenging. Even with early ...
  • Time to fibrinolytics for acute myocardial infarction : reasons for delays at Steve Biko Academic Hospital, Pretoria, South Africa 
    Meel, R.; Goncalves, R. (Health and Medical Publishing Group, 2016-01)
    BACKGROUND. Fibrinolytic therapy is a time-critical intervention proven to reduce mortality and morbidity in patients with ST-elevation myocardial infarction (STEMI). Limited data exist in South Africa (SA) regarding time ...
  • Titrating insulin in patients with type 2 diabetes using a structured self-monitoring blood glucose regimen 
    Kalweit, Kerry Leigh; Van Zyl, Danie G.; Rheeder, Paul (Health and Medical Publishing Group, 2018-08)
    BACKGROUND. Self-monitoring of blood glucose (SMBG) can inform on the timing of hyperglycaemia, but there is currently no standardised approach to utilising these data to improve glycaemic control in patients with type 2 ...
  • Tobacco-derived Lipopolysaccharide, not microbial translocation, as a potential contributor to the pathogenesis of rheumatoid arthritis 
    Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Tikly, Mohammed; Tintinger, Gregory Ronald; Winchow, Lai Ling; Steel, Helen C.; Anderson, Ronald (Hindawi Publishing, 2019)
    Microbial lipopolysaccharides (LPS) have been implicated in the pathogenesis of rheumatoid arthritis (RA), possibly driving a systemic inflammatory response that may trigger the development and/or exacerbation of the ...
  • The treatment of cholesterol : issues, effects and targets 
    Ker, James A. (South African Academy of Family Practice/Primary Care, 2010-11)
    Statins are the most powerful cholesterol lowering drugs currently available. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density ...
  • TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection 
    Boswell, Michael T.; Yindom, Louis-Marie; Hameiri-Bowen, Dan; McHugh, Grace; Dauya, Ethel; Bandason, Tsitsi; Mujuru, Hilda; Esbjörnsson, Joakim; Ferrand, Rashida A.; Rowland-Jones, Sarah (Lippincott Williams and Wilkins, 2021-12)
    OBJECTIVE : Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, ...
  • Under pressure to keep it ticking 
    Ker, James A. (New Media Publishing, 2017-11)
    Most patients with hypertension can develop heart failure. In the Framing Heart Study hypertension preceded the development of heart failure in about 91% of new-onset heart failure during at least mean follow-up of 14.1 ...
  • An unexpected acute coronary syndrome 
    Van Hougenhouck-Tulleken, W.G. (Wesley); Ueckermann, Veronica (Health and Medical Publishing Group, 2019-07)
    Acute coronary syndromes due to coronary artery vasospasm occur rarely and are difficult to diagnose in the acute setting. We present a patient with hypocalcaemia-induced coronary artery vasospasm, which resulted in an ...
  • Unilateral atrial fibrillation - how common is atrial divorce? 
    Ker, James A. (Royal College of Physicians of Edinburgh, 2017-06)
    Atrial brillation is the most common pathologic supraventricular tachycardia. It has many causes, is an expensive disease, impairs quality of life and leads to an increased risk of death. Atrial dissociation is ...
  • An unresolved problem 
    Ker, James A. (Media 24, 2015-04)
    The impact of hypertension as a risk factor on the occurrence of cardiovascular disease clinical events should not be underestimated.
  • An unusual presentation of a catecholamine producing tumour 
    Delport, Eluned F.; Roux, L. (Health & Medical Publishing Group, 2009)
    In patients with pheochromocytomas it is well known that different factors can precipitate an acute pheochromocytoma crisis. Our patient presented with a vesicular skin rash and respiratory distress suggestive of disseminated ...
  • Upper limb pain syndromes 
    Ally, Mahmood Moosa Tar Mahomed (Health and Medical Publishing Group, 2011-08)
    This review addresses common questions about upper limb pain that are encountered in practice.
  • Vertical transmission of HIV among pregnant women who initially had false–negative rapid HIV tests in four South African antenatal clinics 
    Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Quinn, Thomas C.; Stoltz, Anton Carel (Public Library of Science, 2019-12-20)
    INTRODUCTION : There is a risk of mother-to-child transmission of HIV (MTCT) during pregnancy and breastfeeding. The aim of this study was to assess vertical transmission of HIV among pregnant women who initially had ...
  • Vitamin D in acute and chronic disease 
    Ker, James A. (Health and Medical Publishing Group, 2011)
    It has emerged over the past 10-20 years that the change in our lifestyle has led to the widespread deficiency of vitamin D. These lifestyle changes include the avoidance of sunlight (voluntary or greater reliance on ...
  • What are health policy and systems research priorities for universal health coverage in South Africa? 
    Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)
    We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...
  • Willingness of people with Type 2 diabetes to start insulin therapy : evidence from the South African Tshwane Insulin Project (TIP) 
    Ngassa Piotie, Patrick; Wood, Paola Silvia; Webb, Elizabeth M.; Marcus, Tessa S.; Rheeder, Paul (Elsevier, 2020-10)
    AIMS : To determine factors associated with ‘hypothetical willingness’ to start insulin among people with Type 2 diabetes (T2DM). METHODS : A quantitative cross-sectional study with insulin-naïve T2DM patients at 23 primary ...