Browsing Research Articles (Internal Medicine) by Title

Browsing Research Articles (Internal Medicine) by Title

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  • Calcium-dependent potentiation of the pro-inflammatory functions of human neutrophils by tigecycline in vitro 
    Cockeran, Riana; Mutepe, Ndiafhi Daphney; Theron, Annette J.; Tintinger, Gregory Ronald; Steel, Helen C.; Stivaktas, Paraskevi Irene; Richards, Guy A.; Feldman, Charles; Anderson, Ronald (Oxford University Press, 2012)
    OBJECTIVES: Tigecycline is the prototype of the recently introduced, intravenously administered glycylcycline class of antibiotics, developed in response to the increasing problem of antibiotic resistance in Gram-positi ...
  • Carbohydrate-derived fulvic acid wellness drink : its tolerability, safety and effect on disease markers in pre-ART HIV-1 positive subjects 
    Botes, M.E.; Gilada, I.S.; Snyman, J.R.; Labuschagne, J.PL. (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2018)
    BACKGROUND : Many people take wellness drinks on a daily basis to enhance physical and emotional well-being. The safety and/ or efficacy of these are not always known or even established in the populations likely to consume ...
  • Carboxyhaemoglobin levels in water-pipe and cigarette smokers 
    Theron, Ansa; Schultz, Cedric; Ker, James A.; Falzone, Nadia (Health and Medical Publishing Group, 2010-02)
    Water-pipe smoking is growing in popularity, especially among young people, because of the social nature of the smoking session and the assumption that the effects are less harmful than those of cigarette smoking. It has ...
  • Cardiovascular risk calculation 
    Ker, James A. (MedPharm Publications, 2014-05)
    Cardiovascular disease remains a major cause of global mortality and morbidity. Atherosclerosis is the main underlying cause in the majority of cardiovascular disease events. Traditional independent risk factors for car ...
  • A case of paroxysmal nocturnal hemoglobinuria (PNH) in an obstetric patient : a South African perspective 
    Laudin, Garrick; Wium, Lizemarie (SEEd Medical Publishers, 2019-01-16)
    Paroxysmal Nocturnal Hemoglobinuria (PNH) originates from an acquired genetic defect in a multipotent hematopoietic stem cell that becomes stem-cell-like in its ability to survive, expand, and self-renew. PNH is a rare ...
  • A case of unexplained cyanosis 
    Soma, Prashilla; Ellemdin, Shiraz (Clinics Cardiv, 2012-09)
    It is now clear that hepatopulmonary syndrome (HPS) may occur and contribute significantly to gas exchange abnormalities in the setting of other cardiopulmonary abnormalities. Since there is no gold-standard diagnostic ...
  • Case study : a novel use for faecal microbial transplantation 
    Ueckermann, Veronica; Francis, E.W. (NISC (Pty) Ltd, Medpharm Publications, and Informa UK Limited, 2019)
    Faecal microbiota transplantation (FMT) refers to the infusion of faeces from a healthy donor, into the gastrointestinal tract of a recipient patient. There is considerable evidence for the efficacy of FMT for the ...
  • Cavernous transformation of the portal vein a rare phenomenon 
    Bosenberg, L.H.; Thomas, P. (In House Publications, 2022)
    Cavernous transformation of the portal vein is a complication of a prior portal vein thrombosis and carries a very poor prognosis. It is associated with portal hypertension, and the massive ascites that develops as a ...
  • Cefdinir and β-lactamase inhibitor independent efficacy against mycobacterium tuberculosis 
    Srivastava, Shashikant; Thomas, Tania; Howe, Dave; Malinga, Lesibana Anthony; Raj, Prithvi; Alffenaar, Jan-Willem; Gumbo, Tawanda (Frontiers Media, 2021-06-07)
    BACKGROUND : There is renewed interest in repurposing β-lactam antibiotics for treatment of tuberculosis (TB). We investigated efficacy of cefdinir, that withstand the β-lactamase enzyme present in many bacteria, against ...
  • Cervical cancer in low and middle‑income countries 
    Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Kibiki, Gibson; Bates, David O.; Dlamini, Zodwa (Spandidos, 2020)
    Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two histological types, adenocarcinoma and squamous cell carcinoma (SCC); SCC is more common and accounts for 70% of all cases. In 2018 ...
  • A challenging case of hypercalcaemia 
    Ueckermann, Veronica (Health and Medical Publishing Group, 2013)
    Hypercalcaemia is not uncommon in clinical practice. The majority of cases are accounted for by hyperparathyroidism and malignancy. The patient discussed below presented with an unusual case of hypercalcaemia.
  • Changes in prevalence and seasonality of pathogens identified in acute respiratory tract infections in hospitalised individuals in rural and urban settings in South Africa; 2018–2022 
    Davids, Michaela; Johnstone, Siobhan; Mendes, Adriano; Brecht, Gadean; Avenant, Theunis Johannes; Du Plessis, Nicolette Marie; De Villiers, Maryke; Page, N.A. (Nicola); Venter, Marietjie (MDPI, 2024-03)
    Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others occur year-round (rhinovirus and ...
  • Chronic heart failure 
    Ker, James A. (MedPharm Publications, 2015)
    Heart failure is a global problem. It is estimated that approximately 38 million people worldwide experience heart failure, and this number is growing because of the ageing of nations’ populations, but also because patients ...
  • Cigarette smoke condensate attenuates phorbol ester-mediated neutrophil extracellular trap formation 
    Bokaba, Refilwe Philadelphia; Anderson, Ronald; Theron, Annette J.; Tintinger, Gregory Ronald (Makerere University Medical School, 2017-09)
    BACKGROUND : Neutrophil extracellular traps (NETs) constitute a network of chromatin fibres containing histone and antimicrobial peptides that are released by activated neutrophils. NETs protect the host against infection ...
  • Circulating anti-citrullinated peptide antibodies, cytokines and genotype as biomarkers of response to disease-modifying antirheumatic drug therapy in early rheumatoid arthritis 
    Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Meyer, Pieter Willem Adriaan; Musenge, Eustasius; Tintinger, Gregory Ronald; Tikly, Mohammed; Anderson, Ronald (BioMed Central, 2015-05-29)
    BACKGROUND : To measure circulating anti-citrullinated peptide antibodies (ACPA) and cytokines pre- and 6 months post-therapy as a strategy to predict and optimize responses to traditional disease-modifying antirheumatic ...
  • Clinical relevance of small airway disease 
    Ker, James A. (New Media Publishing, 2017-12)
    The bronchial tree continuously divides down to the 23rd generation (division). One consequence of this division is that the mucosal surface area of the airways is relatively larger in the distal lung than in the proximal ...
  • Clofazimine, but not isoniazid or rifampicin, augments platelet activation in vitro 
    Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)
    Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
  • Clues to hepatic histoplasmosis in an immunocompromised patient 
    Soma, Prashilla; Ellemdin, Shiraz (Medpharm Publications, 2009-05)
    Disseminated histoplasmosis can be the initial clue to the presence of AIDS. In HIV infected patients, histoplasmosis can present with unusual manifestations, without a positive exposure history or outside the typical ...
  • Comparison of targeted metagenomics and IS-Pro methods for analysing the lung microbiome 
    Goolam Mahomed, Tanweer; Peters, Remco P.H.; Pretorius, G.H.J.; Mahomed, A. Goolam; Ueckermann, Veronica; Kock, Marleen M.; Ehlers, Marthie Magdaleen (BioMed Central, 2021-08-18)
    BACKGROUND : Targeted metagenomics and IS-Pro method are two of the many methods that have been used to study the microbiome. The two methods target different regions of the 16 S rRNA gene. The aim of this study was to ...
  • Comparison of the diagnostic potential of three anti-citrullinated protein antibodies as adjuncts to rheumatoid factor and CCP in a cohort of South African rheumatoid arthritis patients 
    Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Anderson, Ronald; Tikly, Mohammed (Springer, 2018-06)
    PURPOSE : A retrospective comparison of the prevalence and diagnostic value of anti-Sa, anti-CEP-1, and anti-MCV autoantibodies relative to those of the established autoantibodies, composite RF and anti-CCP-IgG used routinely ...