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Browsing Internal Medicine by Author "Nel, Jan Gert"
Now showing items 1-8 of 8
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)Please read abstract in the article.
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Nel, Jan Gert; Theron, Annette J.; Pool, Roger; Durandt, Chrisna; Tintinger, Gregory Ronald; Anderson, Ronald (AOSIS OpenJournals, 2016-01)The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or containing their spread until effective mobilisation of the slower, adaptive ...
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Nel, Jan Gert; Theron, Annette J.; Durandt, Chrisna; Tintinger, Gregory Ronald; Pool, Roger; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Wiley, 2016-06)The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils ...
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Nel, Jan Gert; Durandt, Chrisna; Theron, Annette J.; Tintinger, Gregory Ronald; Pool, Roger; Richards, Guy A.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Elsevier, 2017-06)OBJECTIVES: Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the ...
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Nel, Jan Gert; Durandt, Chrisna; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2016-08)This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply [10–80 nanograms (ng)/ml], platelet activation and cytosolic Ca2+ concentrations ...
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Tintinger, Gregory Ronald; Theron, Annette J.; Steel, Helen C.; Cholo, Moloko C.; Nel, Jan Gert; Feldman, Charles; Anderson, Ronald (MDPI, 2021-02-26)Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated ...
Now showing items 1-8 of 8