Browsing Internal Medicine by Author "Durandt, Chrisna"

Browsing Internal Medicine by Author "Durandt, Chrisna"

Sort by: Order: Results:

  • Clofazimine, but not isoniazid or rifampicin, augments platelet activation in vitro 
    Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)
    Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
  • Neutrophil extracellular traps and their role in health and disease 
    Nel, Jan Gert; Theron, Annette J.; Pool, Roger; Durandt, Chrisna; Tintinger, Gregory Ronald; Anderson, Ronald (AOSIS OpenJournals, 2016-01)
    The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or containing their spread until effective mobilisation of the slower, adaptive ...
  • Pneumolysin activates neutrophil extracellular trap formation 
    Nel, Jan Gert; Theron, Annette J.; Durandt, Chrisna; Tintinger, Gregory Ronald; Pool, Roger; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Wiley, 2016-06)
    The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils ...
  • Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro 
    Nel, Jan Gert; Durandt, Chrisna; Theron, Annette J.; Tintinger, Gregory Ronald; Pool, Roger; Richards, Guy A.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Elsevier, 2017-06)
    OBJECTIVES: Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the ...
  • Pneumolysin mediates platelet activation in vitro 
    Nel, Jan Gert; Durandt, Chrisna; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2016-08)
    This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply [10–80 nanograms (ng)/ml], platelet activation and cytosolic Ca2+ concentrations ...